SMOKING-RELATED DNA ADDUCTS IN HUMAN GASTRIC CANCERS

被引：52
作者：
DYKE, GW [1 ]
CRAVEN, JL
HALL, R
GARNER, RC
机构：
[1] UNIV YORK,DEPT BIOL,CANC RES UNIT,YORK YO1 5DD,N YORKSHIRE,ENGLAND
[2] YORK DIST GEN HOSP,YORK YO3 7HE,N YORKSHIRE,ENGLAND
来源：
INTERNATIONAL JOURNAL OF CANCER | 1992年 / 52卷 / 06期
关键词：
D O I：
10.1002/ijc.2910520602
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the P-32-post-labelling method. Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/10(8) nucleotides to 60 adducts/10(8) nucleotides. In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non-smokers. These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer.
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页码：847 / 850
页数：4
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