THE INFLUENCE OF STAPHYLOCOCCUS ALPHA-TOXIN ON DNA-REPLICATION IN THE HUMAN-CELLS

被引：0

作者：

KHACHAPURIDZE, GG ^{[1
]}

NERGADZE, SG ^{[1
]}

LAPIASHVILI, NN ^{[1
]}

PANIEVA, YM ^{[1
]}

BARENFELD, LS ^{[1
]}

PLESKACH, NM ^{[1
]}

IMEDADZE, MS ^{[1
]}

机构：

[1] ACAD SCI USSR,INST CYTOL,LENINGRAD,USSR

来源：

TSITOLOGIYA | 1991年 / 33卷 / 08期

关键词：

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The influence of staphylococcus alpha-toxin has been investigated on the duration of S-phase of lymphocyte mitotic cycle and on DNA replication in human fibroblasts in vitro. The duration of the S-phase of lymphocytes was measured by counting labeled metaphases and by making replication curves. Alpha-Toxin in a dose of 3-mu-g/ml enhances the onset of S-phase, which is inhibited at a dose of 33-mu-g/ml of alpha-toxin. The action of alpha-toxin resulted in a decreased rate of replication fork and in a progressive activation of replicon groups. This effect was most prominent at 33-mu-g/ml of alpha-toxin. The data obtained allow to suggest that immunodeficiency of the second order, so characteristic of the staphylococcal sepsis, may be due, in many respects, to suppression of DNA replication.

引用

页码：82 / 89

页数：8

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