DOES MIDAZOLAM SEDATION IN ORAL-SURGERY AFFECT THE POTENCY OR DURATION OF DIFLUNISAL ANALGESIA

被引：0

作者：

RODRIGO, MRC ^{[1
]}

ROSENQUIST, JB ^{[1
]}

机构：

[1] UNIV HONG KONG,DEPT ORAL SURG & ORAL MED,HONG KONG,HONG KONG

来源：

AUSTRALIAN DENTAL JOURNAL | 1990年 / 35卷 / 04期

关键词：

Analgesia; postoperative pain control; sedation;

D O I：

10.1111/j.1834-7819.1990.tb00781.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

A randomized cross‐over study was carried out to determine whether midazolam in doses used for conscious sedation had any effect on the potency or duration of diflunisal, a non‐narcotic analgesic used for postoperative pain in oral surgery. Thirty‐two Hong Kong Chinese patients of either sex, aged between 16 and 28 years, were given either midazolam to supplement local anaesthesia or local anaesthesia alone at one visit and the alternative at the other visit, for surgical removal of bilateral symmetrically impacted third molars. Surgery was carried out on one side only at each visit. Diflunisal was given for postoperative pain relief. Midazolam had no effect on the potency or duration of action of diflunisal. Independent of the method, more patients had better pain relief following the second procedure than following the first, probably due to a degree of adaptation to the pain, at the second visit. 1990 Australian Dental Association

引用

页码：333 / 337

页数：5

共 18 条

[1]

Kanto JH., Midazolam: the first water‐soluble benzodiaze‐pine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia, Pharmacotherapy, 5, pp. 138-155, (1985)

[2]

Rodrigo MRC, Clark RNW., A study of intravenous sedation with diazepam and midazolam for dentistry in Hong Kong Chinese, Anaesth Intens Care, 14, pp. 404-411, (1986)

[3]

Smith MT, Eadie MJ, O'Rourke Brophy T., The pharmacokinetics of midazolam in man, Eur J Clin Pharmol, 19, pp. 271-278, (1981)

[4]

Allonen H., Ziegler G., Klotz U., Midazolam kinetics, Clin Pharmacol Ther, 30, pp. 653-661, (1981)

[5]

Dundee JW, Samuel IO, Wilson DB, Toner W., Howard PJ., Midazolam maleate: a water soluble benzodiazepine: preliminary results, British Journal of Clinical Pharmacology, 9, pp. 305-306, (1980)

[6]

Clark RN, Rodrigo MRC., A comparative study of diazepam and midazolam for IV sedation, J Oral Maxillofac Surg, 44, pp. 860-863, (1986)

[7]

Mantegazza P., Parenti M., Tammiso R., Vita P., Zambotti F., Zonta N., Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam, Br J Pharmacol, 75, pp. 569-572, (1982)

[8]

De Castro PJ, Andrieu S., Dubois A., Van Heuneghem. The use of midazolam for the induction, correction and potenti‐ation of analgesic anaesthesia based on alfentanil, Arzneim-Forsch/Drug Research, 31, pp. 2251-2252, (1981)

[9]

Davies RO., Review of the animal and clinical pharmacology of diflunisal, Pharmacotherapy, 3, pp. 9S-22S, (1983)

[10]

Rodrigo MRC, Chau M., Rosenquist JB., A comparison of paracetamol and diflunisal for pain control following third molar surgery, Int J Oral Maxillofac Surg, 18, pp. 130-132, (1989)

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