Targeting glutamine metabolism in PIK3CA mutant colorectal cancers

被引：13

作者：

Feng, Xiujing

Hao, Yujun

Wang, Zhenghe ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA

来源：

GENES & DISEASES | 2016年 / 3卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.gendis.2016.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We recently reported that PIK3CA mutant colorectal cancers (CRCs) are addicted to glutamine through up-regulation of glutamate pyruvate transaminase 2 (GPT2). A GPT2 inhibitor suppresses in vivo growth of PIK3CA mutant, but not wild-type, CRCs. This study indicates that targeting glutamine may be an effective approach to treat CRCs with PIK3CA mutations. Copyright (C) 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：241 / 243

页数：3

共 9 条

[1] AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas [J].

Elkabets, Moshe ;

Pazarentzos, Evangelos ;

Juric, Dejan ;

Sheng, Qing ;

Pelossof, Raphael A. ;

Brook, Samuel ;

Benzaken, Ana Oaknin ;

Rodon, Jordi ;

Morse, Natasha ;

Yan, Jenny Jiacheng ;

Liu, Manway ;

Das, Rita ;

Chen, Yan ;

Tam, Angela ;

Wang, Huiqin ;

Liang, Jinsheng ;

Gurski, Joseph M. ;

Kerr, Darcy A. ;

Rosell, Rafael ;

Teixido, Cristina ;

Huang, Alan ;

Ghossein, Ronald A. ;

Rosen, Neal ;

Bivona, Trever G. ;

Scaltriti, Maurizio ;

Baselga, Jose .

CANCER CELL, 2015, 27 (04) :533-546

[2] Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer [J].

Gross, Matt I. ;

Demo, Susan D. ;

Dennison, Jennifer B. ;

Chen, Lijing ;

Chernov-Rogan, Tania ;

Goyal, Bindu ;

Janes, Julie R. ;

Laidig, Guy J. ;

Lewis, Evan R. ;

Li, Jim ;

MacKinnon, Andrew L. ;

Parlati, Francesco ;

Rodriguez, Mirna L. M. ;

Shwonek, Peter J. ;

Sjogren, Eric B. ;

Stanton, Timothy F. ;

Wang, Taotao ;

Yang, Jinfu ;

Zhao, Frances ;

Bennett, Mark K. .

MOLECULAR CANCER THERAPEUTICS, 2014, 13 (04) :890-901

[3] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[4] Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer [J].

Hao, Yujun ;

Samuels, Yardena ;

Li, Qingling ;

Krokowski, Dawid ;

Guan, Bo-Jhih ;

Wang, Chao ;

Jin, Zhicheng ;

Dong, Bohan ;

Cao, Bo ;

Feng, Xiujing ;

Xiang, Min ;

Xu, Claire ;

Fink, Stephen ;

Meropol, Neal J. ;

Xu, Yan ;

Conlon, Ronald A. ;

Markowitz, Sanford ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Brunengraber, Henri ;

Willis, Joseph E. ;

LaFramboise, Thomas ;

Hatzoglou, Maria ;

Zhang, Guo-Fang ;

Vogelstein, Bert ;

Wang, Zhenghe .

NATURE COMMUNICATIONS, 2016, 7

[5] Glutamine and cancer: cell biology, physiology, and clinical opportunities [J].

Hensley, Christopher T. ;

Wasti, Ajla T. ;

DeBerardinis, Ralph J. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (09) :3678-3684

[6] Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor [J].

Juric, Dejan ;

Castel, Pau ;

Griffith, Malachi ;

Griffith, Obi L. ;

Won, Helen H. ;

Ellis, Haley ;

Ebbesen, Saya H. ;

Ainscough, Benjamin J. ;

Ramu, Avinash ;

Iyer, Gopa ;

Shah, Ronak H. ;

Huynh, Tiffany ;

Mino-Kenudson, Mari ;

Sgroi, Dennis ;

Isakoff, Steven ;

Thabet, Ashraf ;

Elamine, Leila ;

Solit, David B. ;

Lowe, ScottW. ;

Quadt, Cornelia ;

Peters, Malte ;

Derti, Adnan ;

Schegel, Robert ;

Huang, Alan ;

Mardis, Elaine R. ;

Berger, Michael F. ;

Baselga, Jose ;

Scaltriti, Maurizio .

NATURE, 2015, 518 (7538) :240-U230

[7] Discovery and saturation analysis of cancer genes across 21 tumour types [J].

Lawrence, Michael S. ;

Stojanov, Petar ;

Mermel, Craig H. ;

Robinson, James T. ;

Garraway, Levi A. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Gabriel, Stacey B. ;

Lander, Eric S. ;

Getz, Gad .

NATURE, 2014, 505 (7484) :495-+

[8] High frequency of mutations of the PIK3CA gene in human cancers [J].

Samuels, Y ;

Wang, ZH ;

Bardelli, A ;

Silliman, N ;

Ptak, J ;

Szabo, S ;

Yan, H ;

Gazdar, A ;

Powell, DM ;

Riggins, GJ ;

Willson, JKV ;

Markowitz, S ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

SCIENCE, 2004, 304 (5670) :554-554

[9] Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway [J].

Son, Jaekyoung ;

Lyssiotis, Costas A. ;

Ying, Haoqiang ;

Wang, Xiaoxu ;

Hua, Sujun ;

Ligorio, Matteo ;

Perera, Rushika M. ;

Ferrone, Cristina R. ;

Mullarky, Edouard ;

Ng Shyh-Chang ;

Kang, Ya'an ;

Fleming, Jason B. ;

Bardeesy, Nabeel ;

Asara, John M. ;

Haigis, Marcia C. ;

DePinho, Ronald A. ;

Cantley, Lewis C. ;

Kimmelman, Alec C. .

NATURE, 2013, 496 (7443) :101-+

← 1 →