SYNTHESIS OF CYSTINE-PEPTIDE BY A NEW DISULFIDE BOND-FORMING REACTION USING THE SILYL CHLORIDE-SULFOXIDE SYSTEM

被引：37

作者：

AKAJI, K ^{[1
]}

TATSUMI, T ^{[1
]}

YOSHIDA, M ^{[1
]}

KIMURA, T ^{[1
]}

FUJIWARA, Y ^{[1
]}

KISO, Y ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV,DEPT MED CHEM,YAMASHINA KU,KYOTO 607,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 03期

关键词：

D O I：

10.1039/c39910000167

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methyltrichlorosilane or tetrachlorosilane in trifluoroacetic acid, in the presence of diphenylsulphoxide, is found to cleave various S-protecting groups of cysteine to form cystine directly by the reduction-oxidation reaction; this new disulphide bond forming reaction is successfully applied to the syntheses of oxytocin and human brain natriuretic peptide.

引用

页码：167 / 168

页数：2

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