EFFECTS OF CYCLOPHOSPHAMIDE AND DEXAMETHASONE ON MAST-CELL POPULATIONS IN HYMENOLEPIS-MICROSTOMA-INFECTED MICE

被引：5
作者：
NOVAK, M [1 ]
BUCHANNAN, LG [1 ]
HOWLADER, H [1 ]
机构：
[1] UNIV WINNIPEG,DEPT STAT,WINNIPEG R3B 2E9,MANITOBA,CANADA
来源：
PARASITOLOGY | 1990年 / 100卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
cyclophosphamide; dexamethasone; Hymenolepis microstoma; mast cells;
D O I：
10.1017/S0031182000061357
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Antineoplastic cyclophosphamide (CY) significantly reduced the survival and the weight of Hymenolepis microstoma in mice. Corticosteroid dexamethasone (DEX), on the other hand, did not influence the worm survival and the worms in DEX-treated mice became significantly heavier. Both immunosuppressants abolished H. microstoma-induced bile duct hypertrophy and submucous enteritis and lowered the number of mast cells (MC) in these regions. CY appeared to be more effective in depleting the bile duct MC whereas DEX seemed to affect more the duodenal MC population. © 1990, Cambridge University Press. All rights reserved.
引用
收藏
页码：337 / 343
页数：7
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