2-METHOXY-4-NITROANILINE IS A SELECTIVE INDUCER OF CYTOCHROME P450IA2 (CYP1A2) IN RAT-LIVER

被引：13

作者：

DEGAWA, M

NAKAYAMA, M

YOSHINARI, K

HASHIMOTO, Y

机构：

[1] Department of Hygineic Chemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, 980-77, Aoba, Aramaki-aza

来源：

CANCER LETTERS | 1995年 / 96卷 / 01期

关键词：

2-METHOXY-4-NITROANILINE; CYTOCHROME P450; CYPIA2; INDUCTION; LIVER; RAT;

D O I：

10.1016/0304-3835(95)03910-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Male F344 rats were treated with a chemical (aniline, nitrobenzene, 2-methoxy-p-phenylenediamine, 2-methoxy-4-nitroaniline or 2-methoxy-4-nitroazobenzene) produced by the azo-reduction and/or N-oxidation of 2-methoxy-4-amino-azobenzene, a selective inducer of cytochrome P450IA2 (CYP1A2), and their effects on the induction of CYP1A enzymes in the liver were examined in terms of the protein and mRNA amounts. 2-Methoxy-4-nitroaniline and 2-methoxy-4-nitroazobenzene, but not other compounds tested, induced CYP1A enzymes, especially CYP1A2, as assessed by Western blotting and Northern blotting. It is noteworthy that 2-methoxy-4-nitroaniline was more selective than 2-methoxy-4-aminoazobenzene for induction of CYP1A2, and it has the smallest molecular size among the known CYP1A2 inducers.

引用

页码：95 / 98

页数：4

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