ACETAMINOPHEN AND MACROPHAGE ACTIVATION

被引：6

作者：

GOLDIN, RD

RATNAYAKA, ID

BREACH, CS

WICKRAMASINGHE, SN

机构：

[1] The Division of Pathology Sciences, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1995年 / 4卷 / 01期

关键词：

PARACETAMOL; DRUG; MONOCYTE; TUMOR NECROSIS FACTOR;

D O I：

10.1016/0928-4346(95)00207-Y

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acetominophen is a widely used therapeutic agent which is a relatively common cause of drug - induced liver damage in over dose. When macrophages from healthy individuals are incubated with this drug in vitro there is an increase in the production of the cytokine tumour necrosis factor with a 3-fold increase at drug concentrations between 250 and 500 mu g/mI. This has important implications for the mode of action of this drug and for the treatment of overdoses.

引用

页码：16 / 18

页数：3

共 8 条

[1]

BRENNER S, 1990, ACTA DERM-VENEREOL, V70, P357

[2] ACUTE LIVER NECROSIS FOLLOWING OVERDOSE OF PARACETAMOL [J].

DAVIDSON, DG ;

EASTHAM, WN .

BRITISH MEDICAL JOURNAL, 1966, 2 (5512) :497-&

[3] LARGE VOLUME LIPOSOMES BY AN ETHER VAPORIZATION METHOD [J].

DEAMER, D ;

BANGHAM, AD .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 443 (03) :629-634

[4] GENOTOXIC EFFECTS OF PARACETAMOL IN V79 CHINESE-HAMSTER CELLS [J].

HONGSLO, JK ;

CHRISTENSEN, T ;

BRUNBORG, G ;

BJORNSTAD, C ;

HOLME, JA .

MUTATION RESEARCH, 1988, 204 (02) :333-341

[5]

LASKIN DI, 1986, TOXICOL APPL PHARM, V2, P216

[6] NONPARENCHYMAL CELLS AND HEPATOTOXICITY [J].

LASKIN, DL .

SEMINARS IN LIVER DISEASE, 1990, 10 (04) :293-304

[7]

LASKIN DL, 1989, CELLS HEPATIC SINUSO, V2, P284

[8] PARACETAMOL OVERDOSAGE - PHARMACOLOGICAL CONSIDERATIONS AND CLINICAL MANAGEMENT [J].

PRESCOTT, LF .

DRUGS, 1983, 25 (03) :290-314

← 1 →