CYTOGENETIC CONVERSION IN A CASE OF POLYCYTHEMIA-VERA TREATED WITH INTERFERON-ALPHA

被引：51

作者：

MESSORA, C ^{[1
]}

BENSI, L ^{[1
]}

VECCHI, A ^{[1
]}

LONGO, R ^{[1
]}

GIACOBBI, F ^{[1
]}

TEMPERANI, P ^{[1
]}

BEVINI, M ^{[1
]}

EMILIA, G ^{[1
]}

SACCHI, S ^{[1
]}

机构：

[1] UNIV MODENA,POLICLIN,IST CLIN MED 2,I-41100 MODENA,ITALY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 86卷 / 02期

关键词：

POLYCYTHEMIA VERA; IFN; CHROMOSOME CONVERSION;

D O I：

10.1111/j.1365-2141.1994.tb04752.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycythaemia vera is a clonal disorder of the haemopoietic stem cell causing a pathologic expansion of the erythroid and sometimes the megakaryocytic and myeloid elements. In order to avoid the possible mutagenic effects of radioactive phosphorus, alkylating agents and hydroxyurea, since 1988 cr-IFN has been used for the treatment of PV and has been shown to induce and maintain haematological remission. We describe a 24-year-old PV patient with chromosomal abnormalities who achieved not only a reduction of the proliferation of erythroid elements and reticulin content in the bone marrow, but also a complete cytogenetic remission after IFN treatment.

引用

页码：402 / 404

页数：3