SCH-47918 - A NOVEL PAF ANTAGONIST FROM THE FUNGUS PHOMA SP

被引：41

作者：

CHU, M ^{[1
]}

PATEL, MG ^{[1
]}

GULLO, VP ^{[1
]}

TRUUMEES, I ^{[1
]}

PUAR, MS ^{[1
]}

MCPHAIL, AT ^{[1
]}

机构：

[1] DUKE UNIV,PAUL M GROSS CHEM LAB,DEPT CHEM,DURHAM,NC 27706

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 22期

关键词：

D O I：

10.1021/jo00048a008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel platelet activating factor (PAF) antagonist, Sch 47918, was isolated from the fermentation broth of the fungus, Phoma sp. The structure of this compound was elucidated by spectroscopic methods. The proposed structure and stereochemistry of Sch 47918 were confirmed by single-crystal X-ray diffraction analysis. Sch 47918 was found to be active at IC50 = 6.96 muM in the in vitro PAF-induced human platelet aggregation assay.

引用

页码：5817 / 5818

页数：2

共 6 条

[1]

BRAQUET P, 1987, PHARMACOL REV, V39, P97

[2] THE STRUCTURE OF CLEOMEOLIDE, AN UNUSUAL BICYCLIC DITERPENE FROM CLEOME-VISCOSA L (CAPPARACEAE) [J].

BURKE, BA ;

CHAN, WR ;

HONKAN, VA ;

BLOUNT, JF ;

MANCHAND, PS .

TETRAHEDRON, 1980, 36 (24) :3489-3493

[3]

HENSON PM, 1977, J IMMUNOL, V119, P2179

[4]

KNOVER KA, 1981, NEW ENGL J MED, V304, P1404

[5] STRUCTURE OF CLEOMEOLIDE, A NOVEL DITERPENE LACTONE FROM CLEOME-ICOSANDRA LINN [J].

MAHATO, SB ;

PAL, BC ;

KAWASAKI, T ;

MIYAHARA, K ;

TANAKA, O ;

YAMASAKI, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (16) :4720-4723

[6] PLATELET .2. PHYSIOLOGY AND ABNORMALITIES OF PLATELET-FUNCTION [J].

WEISS, HJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (12) :580-588

← 1 →