SYNTHESIS OF 1-(2,4-DIDEOXY-BETA-D-ERYTHRO-HEXOPYRANOSYL)THYMINE AND ITS INCORPORATION INTO OLIGONUCLEOTIDES

被引：16

作者：

AUGUSTYNS, K ^{[1
]}

VANAERSCHOT, A ^{[1
]}

HERDEWIJN, P ^{[1
]}

机构：

[1] REGA INST,PHARMACEUT CHEM LAB,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80594-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine, starting from the well known carbohydrate precursors 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose (12 steps) or from tri-O-acetyl-D-glucal (11 steps) is described.

引用

页码：945 / 948

页数：4

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