ELEVATED LEVELS OF C-JUN AND C-FOS TRANSCRIPTS IN THE AGED RAT-LIVER

被引：35

作者：

FUJITA, T ^{[1
]}

MARUYAMA, N ^{[1
]}

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT MOLEC PATHOL,TOKYO 173,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91061-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Age-associated increases of transcript levels of several genes were studied using aged rat liver. Northern hybridization showed marked increases of c-jun, c-fos, and glutathione S-transferase P (GST-P) in 24-month-old rats. These genes have the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-responsive element called TRE in their structures. Thus, TRE seems to be involved in important age-associated changes of gene expression. © 1991.

引用

页码：1485 / 1491

页数：7

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