PINK1 and Parkin to control mitochondria remodeling

被引：13

作者：

Koh, Hyongjong ^{[1
]}

Chung, Jongkyeong ^{[2
]}

机构：

[1] Dong A Univ, MHRC, Dept Pharmacol, Coll Med, Busan, South Korea

[2] Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea

来源：

ANATOMY & CELL BIOLOGY | 2010年 / 43卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

PINK1; Parkin; Mitochondria; Parkinson's disease;

D O I：

10.5115/acb.2010.43.3.179

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Parkinson's disease (PD), one of the most common neurodegenerative diseases, is characterized by movement disorders and a loss of dopaminergic (DA) neurons. PD mainly occurs sporadically, but may also result from genetic mutations in several PD-linked genes. Recently, genetic studies with Drosophila mutants, parkin and PINK1, two common PD-associated genes, demonstrated that Parkin acts downstream of PINK1 in maintaining mitochondrial function and integrity. Further studies revealed that PINK1 translocates Parkin to mitochondria and regulates critical mitochondrial remodeling processes. These findings, which suggest that mitochondrial dysfunction is a prominent cause of PD pathogenesis, provide valuable insights which may aid in the development of effective treatments for PD.

引用

页码：179 / 184

页数：6

共 41 条

[31] Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase [J].

Ramirez, Alfredo ;

Heimbach, Andre ;

Gruendemann, Jan ;

Stiller, Barbara ;

Hampshire, Dan ;

Cid, L. Pablo ;

Goebel, Ingrid ;

Mubaidin, Ammar F. ;

Wriekat, Abdul-Latif ;

Roeper, Jochen ;

Al-Din, Amir ;

Hillmer, Axel M. ;

Karsak, Meliha ;

Liss, Birgit ;

Woods, C. Geoffrey ;

Behrens, Maria I. ;

Kubisch, Christian .

NATURE GENETICS, 2006, 38 (10) :1184-1191

[32] Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase [J].

Shimura, H ;

Hattori, N ;

Kubo, S ;

Mizuno, Y ;

Asakawa, S ;

Minoshima, S ;

Shimizu, N ;

Iwai, K ;

Chiba, T ;

Tanaka, K ;

Suzuki, T .

NATURE GENETICS, 2000, 25 (03) :302-305

[33] Parkin is a component of an SCF-like ubipuitin ligase complex and protects postmitotic neurons from kainate excitotoxicity [J].

Staropoli, JF ;

McDermott, C ;

Martinat, C ;

Schulman, B ;

Demireva, E ;

Abeliovich, A .

NEURON, 2003, 37 (05) :735-749

[34] Hereditary early-onset Parkinson's disease caused by mutations in PINK1 [J].

Valente, EM ;

Abou-Sleiman, PM ;

Caputo, V ;

Muqit, MMK ;

Harvey, K ;

Gispert, S ;

Ali, Z ;

Del Turco, D ;

Bentivoglio, AR ;

Healy, DG ;

Albanese, A ;

Nussbaum, R ;

González-Maldonaldo, R ;

Deller, T ;

Salvi, S ;

Cortelli, P ;

Gilks, WP ;

Latchman, DS ;

Harvey, RJ ;

Dallapiccola, B ;

Auburger, G ;

Wood, NW .

SCIENCE, 2004, 304 (5674) :1158-1160

[35] PINK1-dependent recruitment of Parkin to mitochondria in mitophagy [J].

Vives-Bauza, Cristofol ;

Zhou, Chun ;

Huang, Yong ;

Cui, Mei ;

de Vries, Rosa L. A. ;

Kim, Jiho ;

May, Jessica ;

Tocilescu, Maja Aleksandra ;

Liu, Wencheng ;

Ko, Han Seok ;

Magrane, Jordi ;

Moore, Darren J. ;

Dawson, Valina L. ;

Grailhe, Regis ;

Dawson, Ted M. ;

Li, Chenjian ;

Tieu, Kim ;

Przedborski, Serge .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (01) :378-383

[36] The PINK1/Parkin pathway: a mitochondrial quality control system? [J].

Whitworth, Alexander J. ;

Pallanck, Leo J. .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2009, 41 (06) :499-503

[37] PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons [J].

Wood-Kaczmar, Alison ;

Gandhi, Sonia ;

Yao, Zhi ;

Abramov, Andrey S. Y. ;

Miljan, Erik A. ;

Keen, Gregory ;

Stanyer, Lee ;

Hargreaves, Iain ;

Klupsch, Kristina ;

Deas, Emma ;

Downward, Julian ;

Mansfield, Louise ;

Jat, Parmjit ;

Taylor, Joanne ;

Heales, Simon ;

Duchen, Michael R. ;

Latchman, David ;

Tabrizi, Sarah J. ;

Wood, Nicholas W. .

PLOS ONE, 2008, 3 (06)

[38] Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery [J].

Yang, Yufeng ;

Ouyang, Yingshi ;

Yang, Lichuan ;

Beal, M. Flint ;

McQuibban, Angus ;

Vogel, Hannes ;

Lu, Bingwei .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (19) :7070-7075

[39] Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin [J].

Yang, Yufeng ;

Gehrke, Stephan ;

Imai, Yuzuru ;

Huang, Zhinong ;

Ouyang, Yingshi ;

Wang, Ji-Wu ;

Yang, Lichuan ;

Beal, M. Flint ;

Vogel, Hannes ;

Lu, Bingwei .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (28) :10793-10798

[40] Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 [J].

Zhang, Y ;

Gao, J ;

Chung, KKK ;

Huang, H ;

Dawson, VL ;

Dawson, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13354-13359

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