STEPWISE APPROACH TO THE 2,3-DIHYDROIMIDAZO[1,2-A]PYRIDINE AND 5-OXO-1,2,3,5-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE RING-SYSTEMS

被引：9

作者：

PODHOREZ, DE ^{[1
]}

机构：

[1] DOWELANCO,MIDLAND,MI 48640

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 04期

关键词：

D O I：

10.1002/jhet.5570280422

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of 2,3-dihydro-8-fluoro-6-trifluoromethylimidazo[1,2-a]pyridine-3-carbonitrile (2), 8-fluoro-6-trifluoromethylimidazo[1,2-a]pyridine-3-carbonitrile (9) and 5-oxo-8-trifluoromethyl-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-3-carbonitrile (3) are described. These compounds are constructed in a stepwise approach starting from the properly substituted 2-halopyridines.

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页码：971 / 976

页数：6

相关论文

共 16 条

[1] THE REACTION OF ALPHA-DIKETONES WITH PRIMARY HETEROAROMATIC AMINES - SYNTHESIS AND REACTIONS OF IMIDAZO[1,2-A]PYRIDIN-3(2H)-ONES AND NORMAL-HETEROARYL ALPHA-IMINOKETONES [J].

ALCAIDE, B ;

PLUMET, J ;

SIERRA, MA .

TETRAHEDRON, 1989, 45 (21) :6841-6856

[2] DERIVATIVES OF IMIDAZOLE .3. SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF NITRILES AMIDES AND CARBOXYLIC ACID DERIVATIVES OF IMIDAZO(1,2-A)PYRIDINE [J].

ALMIRANTE, L ;

MUGNAINI, A ;

RUGARLI, P ;

GAMBA, A ;

ZEFELIPPO, E ;

DETOMA, N ;

MURMANN, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :122-+

[3] FLUOROCARBON DERIVATIVES OF NITROGEN .11. SYNTHESIS OF SOME 2-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRIDINES FROM TRIFLUOROACETONITRILE [J].

BANKS, RE ;

THOMSON, J .

JOURNAL OF FLUORINE CHEMISTRY, 1984, 26 (04) :499-506

[4]

BLEWITT HL, 1977, CHEM HETEROCYCL COMP, V30, P117

[5]

BOUDAKIAN MM, 1974, PYRIDINE ITS DERIV 2, V14, P407

[6] SYNTHESIS OF IMIDAZO[1,2-A]PYRIDINE AND PYRIDO[1,2-A]PYRIMIDINE DERIVATIVES BY THE ADDITION AND CYCLOCONDENSATION REACTIONS OF KETENAMINALS CONTAINING IMIDAZOLIDINE OR HEXAHYDROPYRIMIDINE RING WITH ESTERS OF ALPHA,BETA-UNSATURATED ACIDS [J].

HUANG, ZT ;

LIU, ZR .

HETEROCYCLES, 1986, 24 (08) :2247-2254

[7]

JONES RCF, 1988, TETRAHEDRON LETT, P5005

[8] ANTIULCER AGENTS .1. GASTRIC ANTISECRETORY AND CYTOPROTECTIVE PROPERTIES OF SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES [J].

KAMINSKI, JJ ;

BRISTOL, JA ;

PUCHALSKI, C ;

LOVEY, RG ;

ELLIOTT, AJ ;

GUZIK, H ;

SOLOMON, DM ;

CONN, DJ ;

DOMALSKI, MS ;

WONG, SC ;

GOLD, EH ;

LONG, JF ;

CHIU, PJS ;

STEINBERG, M ;

MCPHAIL, AT .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (07) :876-892

[9]

KNOLKER HJ, 1989, HETEROCYCLES, V29, P1551

[10] SYNTHESIS OF IMIDAZO[1,2-A]PYRIDINES BY REACTION OF PYRIDINIUM DICYANOMETHYLIDES WITH SODIUM ALKOXIDES [J].

KUTSUMA, T ;

SATO, K ;

CHIDA, T ;

TSUKUNO, Y .

YAKUGAKU ZASSHI, 1970, 90 (03) :251-+