OSCILLATIONS OF MARROW CULTURE-GROWTH IN ACUTE MYELOID-LEUKEMIA DURING REMISSION INDUCTION AND REMISSION

被引：10
|
作者：
GUSTAVSSON, A
OLOFSSON, T
OLSSON, I
机构：
[1] UNIV LUND HOSP,DEPT RES 2,S-22185 LUND,SWEDEN
[2] UNIV LUND HOSP,DEPT INTERNAL MED,S-22185 LUND,SWEDEN
来源：
ACTA HAEMATOLOGICA | 1979年 / 62卷 / 5-6期
关键词：
Acute myeloid leukemia; In vitro culture; Sequential studies;
D O I：
10.1159/000207581
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sequential studies in acute myeloid leukemia of bone marrow cells in agar culture showed striking fluctuations of colony and cluster formation during induction of remission. These oscillations may be initiated by recruitment of resting leukemic and normal ceils upon chemotherapeutic perturbation. Striking oscillations of the colony and cluster formation occurred also during remission with or without maintenance therapy, but with a longer periodicity as compared to the phase of induction of remission. Oscillations of the marrow growth capacity during remission may reflect potential relapses where the outcome depends on proliferative advantages of the normal or leukemic cell clone. © 1979 S. Karger AG, Basel.
引用
收藏
页码：241 / 246
页数：6
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