THE SPECIFICITY OF ANTIGLOBULIN AUTOANTIBODIES IN PATIENTS WITH PRIMARY SJOGRENS-SYNDROME

被引：1

作者：

WADA, T ^{[1
]}

EZAKI, I ^{[1
]}

SHINGU, M ^{[1
]}

NONAKA, S ^{[1
]}

OHTSUKA, E ^{[1
]}

YASUDA, M ^{[1
]}

NOBUNAGA, M ^{[1
]}

机构：

[1] KYUSHY UNIV 69,MED INST BIOREGULAT,DEPT INTERNAL MED,4546 TSURUMIBARU,BEPPU 874,JAPAN

来源：

CLINICAL RHEUMATOLOGY | 1990年 / 9卷 / 04期

关键词：

RHEUMATOID FACTOR; ANTI-FAB ANTIBODY; PRIMARY SJOGRENS SYNDROME; ELISA;

D O I：

10.1007/BF02030512

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiglobulin autoantibodies have already been demonstrated in the sera of patients with primary Sjogren's syndrome (primary SS). In our study, the specificity of primary SS antiglobulins for different regions of IgG molecules was examined by employing both direct binding and competitive inhibition enzyme-linked immunosorbent assay. We found that a considerable amount of total antiglobulins in primary SS was specific for the Fab portion, although the remainder was specific for the Fc portion, namely rheumatoid factor (RF). In contrast, most of the antiglobulins in RA were specific for the Fc portion of IgG. These results indicate that in primary SS, antiglobulins directed against epitopes different from those of RF are produced. These antiglobulins may prove to have a different role in primary SS than that ascribed to RF in RA.

引用

页码：501 / 508

页数：8

共 23 条

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