INTERACTION OF DOUBLE-HELICAL POLYNUCLEAR COPPER(I) COMPLEXES WITH DOUBLE-STRANDED DNA

被引：78

作者：

SCHOENTJES, B ^{[1
]}

LEHN, JM ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,CHIM SUPRAMOLEC LAB,CNRS,URA 422,F-67000 STRASBOURG,FRANCE

来源：

HELVETICA CHIMICA ACTA | 1995年 / 78卷 / 01期

关键词：

D O I：

10.1002/hlca.19950780103

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double-helical metal complexes, the helicates H-2-H-5, were found to bind to double-helical DNA by spectroscopic, DNA-melting, and electrophoretic-mobility measurements. The helicates also inhibited the cleavage of DNA by two restriction enzymes, SspI and EcoRV, a property which agrees with the binding occurring in the major groove of the double helix. Visible-light irradiation of solutions containing a helicate and the pBR322 plasmid led to single-strand cleavage, indicating that these complexes could be of interest as potential probes for nucleic-acid structure.

引用

页码：1 / 12

页数：12

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