USE OF SALIVA IN-HOME MONITORING OF CARBAMAZEPINE LEVELS

被引：29

作者：

ROSENTHAL, E

HOFFER, E

BENARYEH, H

BADARNI, S

BENDERLY, A

HEMLI, Y

机构：

[1] RAMBAM MED CTR, ISRAEL POISON INFORMAT CTR, IL-31096 HAIFA, ISRAEL

[2] RAMBAM MED CTR, DEPT ORAL & MAXILLOFACIAL SURG, ORAL BIOL LAB, IL-31096 HAIFA, ISRAEL

[3] RAMBAM MED CTR, DEPT NEUROL, IL-31096 HAIFA, ISRAEL

[4] TECHNION ISRAEL INST TECHNOL, BRUCE RAPPAPORT FAC MED, IL-31096 HAIFA, ISRAEL

来源：

EPILEPSIA | 1995年 / 36卷 / 01期

关键词：

EPILEPSY; CARBAMAZEPINE; SALIVARY DRUG LEVELS; SERUM DRUG LEVELS; HOME MONITORING;

D O I：

10.1111/j.1528-1157.1995.tb01668.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Total carbamazepine (CBZ) levels in serum of 61 epileptic children were compared with saliva levels. Both resting and stimulated saliva was analyzed. The salivary levels were 38.6% of serum CBZ levers. A highly significant correlation was noted (r = 0.89, p < 0.001). Stimulation had no effect on saliva CBZ levels (r = 0.97). Salivary and serum CBZ levels were not affected by storing the samples for 7 days at room temperature. The data indicate that salivary CBZ may provide a reliable alternative monitoring method to Tegretol therapy, especially in children, in whom blood sampling is difficult. Furthermore, the samples may be collected at home and delivered to the laboratory by mail.

引用

页码：72 / 74

页数：3

共 17 条

[1] USE OF SALIVA IN MONITORING CARBAMAZEPINE MEDICATION IN EPILEPTIC CHILDREN [J].