ALZHEIMERS-DISEASE - A PISCATORIAL TREK

被引：6

作者：

VANEERDEWEGH, P ^{[1
]}

HAMPE, CL ^{[1
]}

SUAREZ, BK ^{[1
]}

REICH, T ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT GENET,ST LOUIS,MO 63110

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 06期

关键词：

AFFECTED-PEDIGREE-MEMBER METHOD; MARKER ALLELE FREQUENCY; KINSHIP COEFFICIENT; ALZHEIMERS DISEASE;

D O I：

10.1002/gepi.1370100611

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The evidence for linkage between Alzheimer's disease and markers on both chromosomes 19 and 21 [Pericak-Vance et al., 1991] by the affected-pedigree-member (APM) method [Weeks and Lange, 19881 cannot be replicated on any of the available GAW8 data sets when marker allele frequencies are estimated from the combined sample. The strong dependence of the APM method on accurate estimation of marker allele frequencies, and the effects of noninformative pairs and of genetic distance in informative pairs of relatives are illustrated. (C) 1993 Wiley-Liss, Inc.

引用

页码：395 / 400

页数：6

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