Correlation of Pap Smear and Colposcopy in Relation to Histopathological Findings in Detection of Premalignant Lesions of Cervix in A Tertiary Care Centre

Objective: Correlation of papanicolaou (PAP) smear and colposcopy in the detection of premalignant lesions of cervix. Materials and Methods: A prospective observational study was conducted in a tertiary care referral institute in 100 symptomatic, sexually active women of 20-65 years. PAP smears were performed by the conventional method and colposcopy was done for all 100 women who came with complaints of white discharge per vagina, intermenstrual, or postcoital bleeding, etc. Final correlation of the PAP smear and colposcopy were based on histopathology reports. Results: In cytology and colposcopy-directed biopsy sensitivity is 65.38%, specificity is 95.83%. Positive predictive value 94.4%, negative predictive value 71.8% and accuracy are 80%. Conclusion: In the present study, incidence of cervical intraepithelial neoplasia I (CIN I) was 28%, CIN II 11%, CIN III 4%, carcinoma in situ 2%, squamous cell carcinoma 5%, and adenocarcinoma 2%. This emphasizes the use of all 3 methods PAP cytology (conventional method), colposcopy, and histology is complementary to each other and helps to reduce false negative cases.