THE EFFECTS OF DISCRETE GAP JUNCTION COUPLING ON PROPAGATION IN MYOCARDIUM

被引：165
作者：
KEENER, JP
机构：
[1] Department of Mathematics, University of Utah, Salt Lake City
来源：
JOURNAL OF THEORETICAL BIOLOGY | 1991年 / 148卷 / 01期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0022-5193(05)80465-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A modified cable theory for a bi-domain model of myocardium that incorporates the effect of gap junctions as discrete objects coupling cardiac cells is derived. The theory is shown to be in agreement with a number of experiments that cannot be explained using standard continuous cable theory, and resolves some apparent contradictions on failure of propagation in two-dimensional anisotropic tissue. In addition, some as yet untested predictions of the theory are mentioned. © 1991 Academic Press Limited.
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页码：49 / 82
页数：34
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