STRUCTURE ELUCIDATION OF RESTRICTICIN, A NOVEL ANTIFUNGAL AGENT FROM PENICILLIUM-RESTRICTUM

被引：31

作者：

HENSENS, OD

WICHMANN, CF

LIESCH, JM

VANMIDDLESWORTH, FL

WILSON, KE

SCHWARTZ, RE

机构：

来源：

TETRAHEDRON | 1991年 / 47卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(01)86432-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures and absolute stereochemistry of restriction (1), its N,N-dimethyl derivative (4) and desglycyl hydrolysis product (3), isolated from Penicillium restrictum, have been determined on the basis of spectroscopic evidence. They belong to a new class of broad spectrum antifungal agents representing substituted tetrahydropyanyl ethers incorporating triene and glycyl ester side chains.

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页码：3915 / 3924

页数：10

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