DNA CYTOPHOTOMETRY IN ADRENOCORTICAL TUMORS - A CLINICOMORPHOLOGICAL STUDY OF 66 CASES

被引：21

作者：

PADBERG, BC

LAURITZEN, I

ACHILLES, E

HOLL, K

BRESSEL, M

KLOPPEL, G

DRALLE, H

SCHRODER, S

机构：

[1] GEN HOSP HAMBURG,DEPT UROL,HARBURG,GERMANY

[2] HANOVER UNIV MED,DEPT SURG,HANNOVER,GERMANY

[3] FREE UNIV BRUSSELS,INST PATHOL,B-1050 BRUSSELS,BELGIUM

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1991年 / 419卷 / 03期

关键词：

ADRENOCORTICAL TUMORS; DNA CYTOPHOTOMETRY; DIFFERENTIAL DIAGNOSIS; PROGNOSIS;

D O I：

10.1007/BF01626343

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Surgical specimens of 66 adrenocortical tumours were investigated by conventional microscopy and DNA cytophotometry. Histologically, 50 neoplasms were classified as adenomas and 16 as carcinomas. In only 8 of the latter cases were distant metastases and/or a lethal outcome recorded. On single cell scanning cytophotometry either non-euploid or aneuploid DNA histograms were identified in 24 of 50 adenomas (48%) and in 14 of 16 carcinomas (88%). The two carcinomas exhibiting euploid DNA distributions fell into the group of 7 malignancies which are recurrence-free so far. From these findings it is concluded that DNA measurements have no diagnostic and only limited prognostic value in neoplasms of the adrenal cortex.

引用

页码：167 / 170

页数：4

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