DNA CYTOPHOTOMETRY IN ADRENOCORTICAL TUMORS - A CLINICOMORPHOLOGICAL STUDY OF 66 CASES

被引：21
|
作者：
PADBERG, BC
LAURITZEN, I
ACHILLES, E
HOLL, K
BRESSEL, M
KLOPPEL, G
DRALLE, H
SCHRODER, S
机构：
[1] GEN HOSP HAMBURG,DEPT UROL,HARBURG,GERMANY
[2] HANOVER UNIV MED,DEPT SURG,HANNOVER,GERMANY
[3] FREE UNIV BRUSSELS,INST PATHOL,B-1050 BRUSSELS,BELGIUM
来源：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1991年 / 419卷 / 03期
关键词：
ADRENOCORTICAL TUMORS; DNA CYTOPHOTOMETRY; DIFFERENTIAL DIAGNOSIS; PROGNOSIS;
D O I：
10.1007/BF01626343
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Surgical specimens of 66 adrenocortical tumours were investigated by conventional microscopy and DNA cytophotometry. Histologically, 50 neoplasms were classified as adenomas and 16 as carcinomas. In only 8 of the latter cases were distant metastases and/or a lethal outcome recorded. On single cell scanning cytophotometry either non-euploid or aneuploid DNA histograms were identified in 24 of 50 adenomas (48%) and in 14 of 16 carcinomas (88%). The two carcinomas exhibiting euploid DNA distributions fell into the group of 7 malignancies which are recurrence-free so far. From these findings it is concluded that DNA measurements have no diagnostic and only limited prognostic value in neoplasms of the adrenal cortex.
引用
收藏
页码：167 / 170
页数：4
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