SEGMENTALLY RESTRICTED, CEPHALIC EXPRESSION OF A LEUCINE ZIPPER GENE DURING DROSOPHILA EMBRYOGENESIS

被引：117
作者：
MOHLER, J
VANI, K
LEUNG, S
EPSTEIN, A
机构：
[1] Barnard College, Department of Biological Sciences, New York, New York
来源：
MECHANISMS OF DEVELOPMENT | 1991年 / 34卷 / 01期
关键词：
BZIP PROTEIN; LEUCINE-ZIPPER; SEGMENTATION GENE; CEPHALIC PATTERNING; DROSOPHILA EMBRYOGENESIS;
D O I：
10.1016/0925-4773(91)90086-L
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The expression pattern and DNA sequence of a newly identified gene, CNC (cap' n' collar), suggest a role for this gene in cephalic patterning during Drosophila embryogenesis. In situ hybridization reveals transcripts localized to the mandibular segment and the hypopharyngeal and labral primordia first detectable in late blastoderm stages. Sequence analysis of cDNA clones from the CNC locus shows the CNC gene product to be related to transcription factors of the leucine zipper (bZIP) class. Based on its protein sequence, we propose that CNC is a subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis.
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页码：3 / 9
页数：7
相关论文
共 62 条
[1]   HUMAN PROTOONCOGENE C-JUN ENCODES A DNA-BINDING PROTEIN WITH STRUCTURAL AND FUNCTIONAL-PROPERTIES OF TRANSCRIPTION FACTOR AP-1 [J].
BOHMANN, D ;
BOS, TJ ;
ADMON, A ;
NISHIMURA, T ;
VOGT, PK ;
TJIAN, R .
SCIENCE, 1987, 238 (4832) :1386-1392
[2]   V-JUN ENCODES A NUCLEAR-PROTEIN WITH ENHANCER BINDING-PROPERTIES OF AP-1 [J].
BOS, TJ ;
BOHMANN, D ;
TSUCHIE, H ;
TJIAN, R ;
VOGT, PK .
CELL, 1988, 52 (05) :705-712
[3]   THE EXPRESSION OF 3 MEMBERS OF THE ACHAETE-SCUTE GENE-COMPLEX CORRELATES WITH NEUROBLAST SEGREGATION IN DROSOPHILA [J].
CABRERA, CV ;
MARTINEZARIAS, A ;
BATE, M .
CELL, 1987, 50 (03) :425-433
[4]   DAUGHTERLESS, A DROSOPHILA GENE ESSENTIAL FOR BOTH NEUROGENESIS AND SEX DETERMINATION, HAS SEQUENCE SIMILARITIES TO MYC AND THE ACHAETE-SCUTE COMPLEX [J].
CAUDY, M ;
VASSIN, H ;
BRAND, M ;
TUMA, R ;
JAN, LY ;
JAN, YN .
CELL, 1988, 55 (06) :1061-1067
[5]   ALPHA-HELICAL COILED COILS - A WIDESPREAD MOTIF IN PROTEINS [J].
COHEN, C ;
PARRY, DAD .
TRENDS IN BIOCHEMICAL SCIENCES, 1986, 11 (06) :245-248
[6]   FRA-1 - A SERUM-INDUCIBLE, CELLULAR IMMEDIATE-EARLY GENE THAT ENCODES A FOS-RELATED ANTIGEN [J].
COHEN, DR ;
CURRAN, T .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) :2063-2069
[7]   THE PRODUCT OF A FOS-RELATED GENE, FRA-1, BINDS COOPERATIVELY TO THE AP-1 SITE WITH JUN - TRANSCRIPTION FACTOR AP-1 IS COMPRISED OF MULTIPLE PROTEIN COMPLEXES [J].
COHEN, DR ;
FERREIRA, PCP ;
GENTZ, R ;
FRANZA, BR ;
CURRAN, T .
GENES & DEVELOPMENT, 1989, 3 (02) :173-184
[8]   MEDIATION OF DROSOPHILA HEAD DEVELOPMENT BY GAP-LIKE SEGMENTATION GENES [J].
COHEN, SM ;
JURGENS, G .
NATURE, 1990, 346 (6283) :482-484
[9]   SYNERGISTIC ACTIVATION BY THE GLUTAMINE-RICH DOMAINS OF HUMAN TRANSCRIPTION FACTOR SP1 [J].
COUREY, AJ ;
HOLTZMAN, DA ;
JACKSON, SP ;
TJIAN, R .
CELL, 1989, 59 (05) :827-836
[10]   FBJ MURINE OSTEO-SARCOMA VIRUS - IDENTIFICATION AND MOLECULAR-CLONING OF BIOLOGICALLY-ACTIVE PROVIRAL DNA [J].
CURRAN, T ;
PETERS, G ;
VANBEVEREN, C ;
TEICH, NM ;
VERMA, IM .
JOURNAL OF VIROLOGY, 1982, 44 (02) :674-682
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