Bone healing in 2016

被引：102

作者：

Buza, John A., III ^{[1
]}

Einhorn, Thomas ^{[1
]}

机构：

[1] NYU, Hosp Joint Dis, Langone Med Ctr, New York, NY 10003 USA

来源：

CLINICAL CASES IN MINERAL AND BONE METABOLISM | 2016年 / 13卷 / 02期

关键词：

fracture; healing; nonunion; bone defects; growth factors;

D O I：

10.11138/ccmbm/2016.13.2.101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Delayed fracture healing and nonunion occurs in up to 5-10% of all fractures, and can present a challenging clinical scenario for the treating physician. Methods for the enhancement of skeletal repair may benefit patients that are at risk of, or have experienced, delayed healing or nonunion. These methods can be categorized into either physical stimulation therapies or biological therapies. Physical stimulation therapies include electrical stimulation, low-intensity pulsed ultrasonography, or extracorporeal shock wave therapy. Biological therapies can be further classified into local or systemic therapy based on the method of delivery. Local methods include autologous bone marrow, autologous bone graft, fibroblast growth factor-2, platelet-rich plasma, platelet-derived growth factor, and bone morphogenetic proteins. Systemic therapies include parathyroid hormone and bisphosphonates. This article reviews the current applications and supporting evidence for the use of these therapies in the enhancement of fracture healing.

引用

页码：101 / 105

页数：5

共 55 条

[1] The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery A REVIEW OF THE LITERATURE [J].

Alsousou, J. ;

Thompson, M. ;

Hulley, P. ;

Noble, A. ;

Willett, K. .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2009, 91B (08) :987-996

[2]

[Anonymous], 2002, NATL TRAUMA DATA BAN

[3] Recombinant Human Bone Morphogenetic Protein-2: A Randomized Trial in Open Tibial Fractures Treated with Reamed Nail Fixation [J].

Aro, Hannu T. ;

Govender, Shunmugam ;

Patel, Amratlal D. ;

Hernigou, Philippe ;

Perera de Gregorio, Arturo ;

Popescu, Gheorghe Ion ;

Golden, Jane Davis ;

Christensen, Jared ;

Valentin, Alexandre .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2011, 93A (09) :801-808

[4] Teriparatide for Acceleration of Fracture Repair in Humans: A Prospective, Randomized, Double-Blind Study of 102 Postmenopausal Women With Distal Radial Fractures [J].

Aspenberg, Per ;

Genant, Harry K. ;

Johansson, Torsten ;

Nino, Antonio J. ;

See, Kyoungah ;

Krohn, Kelly ;

Garcia-Hernandez, Pedro A. ;

Recknor, Christopher P. ;

Einhorn, Thomas A. ;

Dalsky, Gail P. ;

Mitlak, Bruce H. ;

Fierlinger, Anke ;

Lakshmanan, Mark C. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (02) :404-414

[5] Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment [J].

Barnes, George L. ;

Kakar, Sanjeev ;

Vora, Siddarth ;

Morgan, Elise E. ;

Gerstenfeld, Louis C. ;

Einhorn, Thomas A. .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2008, 90A :120-127

[6] A lack of consensus in the assessment of fracture healing among orthopedic surgeons [J].

Bhandari, M ;

Guyatt, GH ;

Swiontkowski, MF ;

Tornetta, P ;

Sprague, S ;

Schemitsch, EH .

JOURNAL OF ORTHOPAEDIC TRAUMA, 2002, 16 (08) :562-566

[7] Assessment of Compromised Fracture Healing [J].

Bishop, Julius A. ;

Palanca, Ariel A. ;

Bellino, Michael J. ;

Lowenberg, David W. .

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2012, 20 (05) :273-282

[8] THE TREATMENT OF NON-UNIONS WITH ELECTRICITY [J].

BRIGHTON, CT .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1981, 63 (05) :847-851

[9]

BRIGHTON CT, 1992, CLIN ORTHOP RELAT R, P255

[10] Low intensity pulsed ultrasonography for fractures: systematic review of randomised controlled trials [J].

Busse, Jason W. ;

Kaur, Jagdeep ;

Mollon, Brent ;

Bhandari, Mohit ;

Tornetta, Paul, III ;

Schuenemann, Holger J. ;

Guyatt, Gordon H. .

BMJ-BRITISH MEDICAL JOURNAL, 2009, 338

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