Gut microbiome and metabolic syndrome

被引:130
作者
Mazidi, Mohsen [1 ,2 ]
Rezaie, Peyman [3 ]
Kengne, Andre Pascal [4 ,5 ]
Mobarhan, Majid Ghayour [3 ,6 ]
Ferns, Gordon A. [7 ]
机构
[1] Chinese Acad Sci, Key State Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China
[2] Univ Chinese Acad Sci, Int Coll, Inst Genet & Dev Biol, West Beichen Rd, Chaoyang, Peoples R China
[3] Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran
[4] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa
[5] Univ Cape Town, Cape Town, South Africa
[6] MUMS, Cardiovasc Res Ctr, Mashhad, Iran
[7] Univ Brighton, Brighton & Sussex Med Sch, Div Med Educ, Rm 342,Mayfield House, Brighton BN1 9PH, E Sussex, England
关键词
Metabolic syndrome; Microbiome; Human gut; Diet;
D O I
10.1016/j.dsx.2016.01.024
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The gut microbiome contributes approximately 2 kg of the whole body weight, and recent studies suggest that gut microbiota has a profound effect on human metabolism, potentially contributing to several features of the metabolic syndrome. Metabolic syndrome is defined by a clustering of metabolic disorders that include central adiposity with visceral fat accumulation, dyslipidemia, insulin resistance, dysglycemia and non-optimal blood pressure levels. Metabolic syndrome is associated with an increased risk of cardiovascular diseases and type 2 diabetes. It is estimated that around 20-25 percent of the world's adult population has metabolic syndrome. In this manuscript, we have reviewed the existing data linking gut microbiome with metabolic syndrome. Existing evidence from studies both in animals and humans support a link between gut microbiome and various components of metabolic syndrome. Possible pathways include involvement with energy homeostasis and metabolic processes, modulation of inflammatory signaling pathways, interferences with the immune system, and interference with the renin-angiotensin system. Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome. (C) 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:S150 / S157
页数:8
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