CD40-CD40 LIGAND (CD40L) INTERACTIONS AND X-LINKED HYPERIGM SYNDROME (HIGMX-1)

被引：20

作者：

RAMESH, N ^{[1
]}

MORIO, T ^{[1
]}

FULEIHAN, R ^{[1
]}

WORM, M ^{[1
]}

HORNER, A ^{[1
]}

TSITSIKOV, E ^{[1
]}

CASTIGLI, E ^{[1
]}

GEHA, RS ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 76卷 / 03期

关键词：

D O I：

10.1016/S0090-1229(95)90252-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression. (C) 1995 Academic Press, Inc.

引用

页码：S208 / S213

页数：6

共 50 条

[31] Readministration of adenovirus vector in nonhuman primate lungs by blockade of CD40-CD40 ligand interactions
Chirmule, N
Raper, SE
Burkly, L
Thomas, D
Tazelaar, J
Hughes, JV
Wilson, JM
JOURNAL OF VIROLOGY, 2000, 74 (07) : 3345 - 3352
[32] CD40-CD40 ligand interactions induce endothelial cell adhesion molecules and secretion of chemokines
Grafe, M
Henn, V
Holzmeister, J
Kroczek, RA
Kintscher, U
Fleck, E
CIRCULATION, 1998, 98 (17) : 593 - 593
[33] Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
Soong, L
Xu, JC
Grewal, IS
Kima, P
Sun, JR
Longley, BJ
Ruddle, NH
McMahonPratt, D
Flavell, RA
IMMUNITY, 1996, 4 (03) : 263 - 273
[34] CD40-CD40 ligand interactions augment survival of normal mice, but not CD40 ligand knockout mice, challenged orally with Salmonella dublin
Marriott, I
Thomas, EK
Bost, KL
INFECTION AND IMMUNITY, 1999, 67 (10) : 5253 - 5257
[35] Regulation of CD40 ligand (CD40L) expression in rheumatoid synovium.
Kirou, K
Crow, MK
FASEB JOURNAL, 2001, 15 (04): : A361 - A361
[36] Functions of CD40 and its Ligand, gp39 (CD40L)
Laman, JD
Claassen, E
Noelle, RJ
CRITICAL REVIEWS IN IMMUNOLOGY, 1996, 16 (01) : 59 - 108
[37] CD40 ligand mutants responsible for x-linked hyper-IGM syndrome associate with wild type CD40L.
Seyama, K
Osborne, WRA
Ochs, HD
FASEB JOURNAL, 1999, 13 (04): : A642 - A642
[38] Functions of CD40 and Its Ligand, gp39 (CD40L)
Leman, Jon D.
Claassen, Eric
Noelle, Randolph J.
CRITICAL REVIEWS IN IMMUNOLOGY, 2017, 37 (2-6) : 371 - 420
[39] INTERACTION BETWEEN CD40 AND ITS LIGAND CD40L IN HUMAN SLE
DESAIMEHTA, A
RAMSEYGOLDMAN, R
DATTA, SK
ARTHRITIS AND RHEUMATISM, 1995, 38 (09): : 969 - 969
[40] CD40L-Deficient Patient Showing Normal Expression of CD40L Demonstrates the Need of Functional Binding Assay of CD40L to CD40-Ig for the Precise Screening of CD40L Deficiency
Lambert, Christiane Guedes
Cabral-Marques, Otavio
Franca, Tabata Takahashi
Costa-Carvalho, Beatriz Tavares
Condino-Neto, Antonio
JOURNAL OF CLINICAL IMMUNOLOGY, 2015, 35 : S33 - S34

← 1 2 3 4 5 →