CD40-CD40 LIGAND (CD40L) INTERACTIONS AND X-LINKED HYPERIGM SYNDROME (HIGMX-1)

被引：20

作者：

RAMESH, N ^{[1
]}

MORIO, T ^{[1
]}

FULEIHAN, R ^{[1
]}

WORM, M ^{[1
]}

HORNER, A ^{[1
]}

TSITSIKOV, E ^{[1
]}

CASTIGLI, E ^{[1
]}

GEHA, RS ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 76卷 / 03期

关键词：

D O I：

10.1016/S0090-1229(95)90252-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression. (C) 1995 Academic Press, Inc.

引用

页码：S208 / S213

页数：6

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