CHIRAL SEPARATION OF DINICONAZOLE, UNICONAZOLE AND STRUCTURALLY RELATED-COMPOUNDS BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY

被引：29
|
作者：
FURUTA, R
DOI, T
机构：
[1] Environmental Health Science Laboratory, Sumitomo Chemical Company, Osaka
来源：
ELECTROPHORESIS | 1994年 / 15卷 / 10期
关键词：
D O I：
10.1002/elps.11501501201
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Enantiomeric separation of the structural analogs, diniconazole and uniconazole, can be achieved by cyclodextrin (CD)-modified micellar electrokinetic chromatography (MEKC). The elution behavior of other structurally related compounds was therefore investigated and compared with that in highperformance liquid chromatography (HPLC) using a CD-bonded stationary phase. From the results, it was concluded that the benzene ring of the solute plays an important role in formation of CD complexes and chiral recognition in MEKC as well as in HPLC, although the enantioselectivity with the two methods was different. Nuclear magnetic resonance (NMR) data revealed different CD effects on the solute between the MEKC and HPLC models.
引用
收藏
页码：1322 / 1325
页数：4
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