REACTIVE ASTROCYTES EXPRESS THE EMBRYONIC INTERMEDIATE NEUROFILAMENT NESTIN

被引：226

作者：

CLARKE, SR

SHETTY, AK

BRADLEY, JL

TURNER, DA

机构：

[1] DUKE UNIV,MED CTR,DURHAM,NC 27710

[2] VET ADM MED CTR,DURHAM,NC 27710

来源：

NEUROREPORT | 1994年 / 5卷 / 15期

关键词：

NESTIN; REACTIVE ASTROCYTE; HIPPOCAMPUS; KAINIC ACID; NEUROTROPHIC FACTORS; IMMUNOCYTOCHEMISTRY; NEUROFILAMENT; GLIAL FIBRILLARY ACIDIC PROTEIN;

D O I：

10.1097/00001756-199410000-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NESTIN is a neurofilament protein expressed by the immediate precursors to neurons and glia in rats and humans. Nestin immunoreactivity in the rat CNS was studied following kainic acid (KA) hippocampal lesions. Numerous nestin positive cells within the KA lesion were confirmed to be reactive astrocytes by their immunoreactivity for glial fibrillary acidic protein (GFAP). The number of these cells decreased with time after the KA lesion and no astrocyte immunostaining for nestin was observed in control animals. A subset of nestin-positive cells in the ventricular subependymal region appeared to be radial glial cells, extending to cell body layers. Nestin is one of several embryonic markers expressed by reactive astrocytes, suggesting an embryonic reversion induced by the KA lesion, possibly to enhance functional recovery.

引用

页码：1885 / 1888

页数：4

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