SYNTHESIS, IN-VITRO AND IN-VIVO ANTIBACTERIAL ACTIVITY OF 7-(7-METHYL-2,5-DIAZABICYCLO[2.2.1]HEPTANE)NAPHTHYRIDONE DERIVATIVES AS ANALOGS OF BMY 40062

被引：6

作者：

REMUZON, P ^{[1
]}

BOUZARD, D ^{[1
]}

CLEMENCIN, C ^{[1
]}

DUSSY, C ^{[1
]}

JACQUET, JP ^{[1
]}

FUNGTOMC, J ^{[1
]}

KESSLER, RE ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES & DEV DIV,WALLINGFORD,CT 06492

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 06期

关键词：

QUINOLONES; NAPHTHYRIDINES; ANTIBACTERIAL ACTIVITY; METHYL BRIDGED PIPERAZINES;

D O I：

10.1016/0223-5234(93)90013-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the antimicrobial activities of chiral (1R,4R,7S)- and (1S,4S,7S)-[7-methyl-2,5-diazabicyclo[2.2.1]-heptan-2-yl] analogs of BMY 40062 are reported. The new derivatives have been found to be less active in vitro but as active in vivo (im) than BMY 40062. The IR,4R,7S substituent seems promising for the design of powerful new antibiotics.

引用

页码：455 / 461

页数：7

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