BEHAVIORS OF RATS WITH INSIDIOUS, MULTIFOCAL BRAIN-DAMAGE INDUCED BY SEIZURES FOLLOWING SINGLE PERIPHERAL INJECTIONS OF LITHIUM AND PILOCARPINE

被引：78

作者：

PERSINGER, MA ^{[1
]}

BUREAU, YRJ ^{[1
]}

KOSTAKOS, M ^{[1
]}

PEREDERY, O ^{[1
]}

FALTER, H ^{[1
]}

机构：

[1] LAURENTIAN UNIV,BIOCHEM PROGRAM,SUDBURY P3E 2C6,ONTARIO,CANADA

来源：

PHYSIOLOGY & BEHAVIOR | 1993年 / 53卷 / 05期

关键词：

RADIAL ARM MAZE (RAM); CONDITIONED TASTE AVERSION (CTA); LITHIUM; LIMBIC SEIZURE; MEMORY; ACETYLCHOLINE; BRAIN DAMAGE;

D O I：

10.1016/0031-9384(93)90261-D

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine. These rats displayed enhanced intragroup aggression but normal muricide; gustatory neophobia and conditioned taste aversion were virtually eliminated. Severe working and reference memory deficits were evident within the radial arm maze. Both state-dependent memory and possible situation-dependent precipitation of spontaneous seizures were suggested. The behavioral changes were considered commensurate with the multifocal pattern of thalamic, hippocampal/amygdaloid, and limbic cortical damage.

引用

页码：849 / 866

页数：18

共 48 条

[21] CORTICAL SUBSTRATES OF TASTE-AVERSION LEARNING - INVOLVEMENT OF DORSOLATERAL AMYGDALOID NUCLEI AND TEMPORAL NEOCORTEX IN TASTE-AVERSION LEARNING [J].

LASITER, PS ;

GLANZMAN, DL .

BEHAVIORAL NEUROSCIENCE, 1985, 99 (02) :257-+

[22] TASTE DISCRIMINATIONS IN RATS LACKING ANTERIOR INSULAR GUSTATORY NEOCORTEX [J].

LASITER, PS ;

DEEMS, DA ;

OETTING, RL ;

GARCIA, J .

PHYSIOLOGY & BEHAVIOR, 1985, 35 (02) :277-285

[23] THALAMOCORTICAL RELATIONS IN TASTE-AVERSION LEARNING .2. INVOLVEMENT OF THE MEDIAL VENTROBASAL THALAMIC COMPLEX IN TASTE-AVERSION LEARNING [J].

LASITER, PS .

BEHAVIORAL NEUROSCIENCE, 1985, 99 (03) :477-+

[24]

LEDOUX JE, 1990, J NEUROSCI, V10, P1043

[25] STIMULATION OF LATERAL HYPOTHALAMUS DURING SICKNESS ATTENUATES LEARNED FLAVOR AVERSIONS [J].

LETT, BT ;

HARLEY, CW .

PHYSIOLOGY & BEHAVIOR, 1974, 12 (01) :79-83

[26] VISCERAL CORTEX LESIONS BLOCK CONDITIONED TASTE-AVERSIONS INDUCED BY MORPHINE [J].

MACKEY, WB ;

KELLER, J ;

VANDERKOOY, D .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 24 (01) :71-78

[27] CONDITIONED-RESPONSES TO A TASTE CONDITIONED-STIMULUS PAIRED WITH LITHIUM-CHLORIDE ADMINISTRATION [J].

MEACHUM, CL ;

BERNSTEIN, IL .

BEHAVIORAL NEUROSCIENCE, 1990, 104 (05) :711-715

[28] LESIONS OF THE CAUDATE-NUCLEUS SELECTIVELY IMPAIR REFERENCE MEMORY ACQUISITION IN THE RADIAL MAZE [J].

PACKARD, MG ;

WHITE, NM .

BEHAVIORAL AND NEURAL BIOLOGY, 1990, 53 (01) :39-50

[29]

Paxinos G., 1986, BRAIN NAVIGATOR, Vsecond

[30] ABSENCE OF MATERNAL-BEHAVIOR IN RATS WITH LITHIUM PILOCARPINE SEIZURE-INDUCED BRAIN-DAMAGE - SUPPORT OF MACLEAN TRIUNE BRAIN THEORY [J].

PEREDERY, O ;

PERSINGER, MA ;

BLOMME, C ;

PARKER, G .

PHYSIOLOGY & BEHAVIOR, 1992, 52 (04) :665-671

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