Evaluation of vitamin D status in children with refractory epilepsy

被引:0
作者
Karaoglu, Pakize [1 ]
Polat, Ayse Ipek [1 ]
Ayanoglu, Muge [1 ]
Yis, Uluc [1 ]
Hiz, Semra [1 ]
机构
[1] Dokuz Eytut Univ, Tip Fak, Cocuk Norol Bilim Dali, Izmir, Turkey
来源
IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI | 2014年 / 4卷 / 03期
关键词
Children; refractory epilepsy; vitamin D;
D O I
10.5222/buchd.2014.167
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Vitamin D deficiency has been reported in children using antiepileptic drugs. Multiple antiepileptic drugs may conceivably increase the risk of vitamin D deficiency. The aim of this study is to determine vitamin D status and risk factors for vitamin D deficiency in children with refractory epilepsy. Methods: Forty children with refractory epilepsy evaluated in our tertiary pediatric neurology outpatient clinic were included in the study, and serum 25-hydroxy vitamin D, parathyroid hormone, calcium, phosphate and alkaline phosphatase levels were assessedd. Vitamin D deficiency was defined as 25-hydroxy vitamin D levels < 20 ng/mL, and insufficiency between 21 and 29 ng/mL. Correlations between vitamin D levels and type of epilepsy (generalized or localized), etiology of epilepsy (symptomatic vs idiopathic), body mass index, frequency of seizures, number, and type (old or new; enzyme inducing or not) of antiepileptic drugs, presence of intellectual disability, ambulatory status and gross motor function classification scores were evaluated. Results: The study group consisted of 17 boys and 23 girls with a mean age of 6.65 +/- 5.29 years. Vitamin D deficiency was identified in 25 (62.5%) and insufficiency in 6 (15%) the patients. There was no correlation between vitamin D levels and type of epilepsy, etiology of epilepsy, body mass index, seizure frequency, number of antiepileptic drugs, type of antiepileptic drugs, presence of intellectual disability, ambulatory status and gross motor function classification scores. Conclusion: We found that vitamin D deficiency was increased in this cohort of children with refractory epilepsy. Vitamin D level should be monitored in patients with refractory epilepsy irrespective of the potential risk factors.
引用
收藏
页码:167 / 170
页数:4
相关论文
共 15 条
  • [1] Frequency of vitamin D insufficiency in healthy children between 1 and 16 years of age in Turkey
    Akman, Alkim Oden
    Tumer, Leyla
    Hasanoglu, Alev
    Ilhan, Mustafa
    Cayci, Banu
    [J]. PEDIATRICS INTERNATIONAL, 2011, 53 (06) : 968 - 973
  • [2] Vitamin D Deficiency in Children and Adolescents
    Andiran, Nesibe
    Celik, Nurullah
    Akca, Halise
    Dogan, Guzide
    [J]. JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, 2012, 4 (01) : 25 - 29
  • [3] Vitamin D status in children with intractable epilepsy, and impact of the ketogenic diet
    Bergqvist, A. G. Christina
    Schall, Joan I.
    Stallings, Virginia A.
    [J]. EPILEPSIA, 2007, 48 (01) : 66 - 71
  • [4] Fong CY, 2013, J CHILD NEUROL
  • [5] Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy
    Guo, CY
    Ronen, GM
    Atkinson, SA
    [J]. EPILEPSIA, 2001, 42 (09) : 1141 - 1147
  • [6] Harijan Pooja, 2013, J Pediatr Neurosci, V8, P5, DOI 10.4103/1817-1745.111413
  • [7] Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study
    Hollo, Andras
    Clemens, Zsofia
    Kamondi, Anita
    Lakatos, Peter
    Szucs, Anna
    [J]. EPILEPSY & BEHAVIOR, 2012, 24 (01) : 131 - 133
  • [8] Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 2001-2004
    Kumar, Juhi
    Muntner, Paul
    Kaskel, Frederick J.
    Hailpern, Susan M.
    Melamed, Michal L.
    [J]. PEDIATRICS, 2009, 124 (03) : E362 - E370
  • [9] Masvidal Aliberch R. M, 2012, AN PEDIAT BARC, V77, P279
  • [10] Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy
    Nettekoven, Sina
    Stroehle, Alexander
    Trunz, Birgit
    Wolters, Maike
    Hoffmann, Susanne
    Horn, Ruediger
    Steinert, Martin
    Brabant, Georg
    Lichtinghagen, Ralf
    Welkoborsky, Hans-Juergen
    Tuxhorn, Ingrid
    Hahn, Andreas
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 2008, 167 (12) : 1369 - 1377