A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Pancytopenia

被引：0

作者：

Lee, Jun Seok ^{[1
]}

Park, Young Sook ^{[1
]}

Kim, Nam In ^{[1
]}

Jo, Yoon Ju ^{[1
]}

Kim, Seung Hwan ^{[1
]}

Lee, Han Hyo ^{[1
]}

Song, Moon Hee ^{[1
]}

Jun, Dae Won ^{[1
]}

机构：

[1] Eulji Univ, Coll Med, Dept Internal Med, Seoul, South Korea

来源：

INTESTINAL RESEARCH | 2008年 / 6卷 / 01期

关键词：

Azathioprine; Pancytopenia; Colitis; Ulcerative;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease. Bone marrow suppression is a common side effect with AZA treatment. However, data from AZA trials has indicated that a leukocyte count less than 5,000/mm(3) was a good predictor of induction and maintenance of remission. Moreover, there is evidence that eradication of sensitized leukocytes by leukapheresis or bone marrow transplantation improves inflammatory bowel disease. We report a case of a patient who had a chronic relapse of ulcerative colitis requiring the frequent use of systemic steroids, but presented prolonged remission following AZA-induced severe pancytopenia. Also colonoscopy showed accelerated healing of diffuse active ulcers following just recovery from pancytopenia.

引用

页码：85 / 89

页数：5

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