Determination of clindamycin hydrochloride content in 1% clindamycin lotion

Clindamycin is a broad spectrum antibiotic that belongs to the lincosamide group. It acts mostly as a bacteriostatic antibiotic, but it also has mild bactericidal activity. The most common clinical conditions in which they are used are: infections in gynecology, gingiva infections, respiratory tract, skin and soft tissue infections, intra-abdominal infections, pneumonia caused by Pneumocystis jiroveci, toxoplasmosis, malaria, babesiosis, and acne. Clindamycin is available in several pharmaceutical forms, which can be administered orally, intravenously, intramuscularly or intradermally. It is usually prepared as an ex tempore 1% clindamycin lotion that is used dermally, in the treatment of a mild form of acne. The proposed UV-Vis spectrophotometric method allows analyzing the content of clindamycin hydrochloride in the extemporaneous formulation of 1% clindamycin lotion. Clindamycin chloride content analysis was performed on samples of 1% clindamycin lotions purchased in pharmacies in Canton Sarajevo. The results showed that the content of clindamycin hydrochloride in the ex tempore prepared preparations varied from 21% to 142%. The UV-Vis method does not require complicated preparation of the sample, and is therefore fast, reliable and economical, and as such can be used in regular control of the content of clindamycin hydrochloride in ex tempore prepared lotion.