THE MULTIDRUG EFFLUX TRANSPORTER OF BACILLUS-SUBTILIS IS A STRUCTURAL AND FUNCTIONAL HOMOLOG OF THE STAPHYLOCOCCUS NORA PROTEIN

被引：102
|
作者：
NEYFAKH, AA
机构：
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 02期
关键词：
D O I：
10.1128/AAC.36.2.484
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The Bacillus subtilis multidrug efflux transporter Bmr demonstrates 44% amino acid sequence identity with a product of the Staphylococcus aureus gene norA, which is responsible for clinically relevant resistance to fluoroquinolones. We show here that overexpression of bmr in B. subtilis provides strong resistance to fluoroquinolones that can be reversed by reserpine, an inhibitor of Bmr.
引用
收藏
页码：484 / 485
页数：2
相关论文
共 50 条
  • [41] Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus
    Vidaillac, Celine
    Guillon, Jean
    Arpin, Corinne
    Forfar-Bares, Isabelle
    Ba, Boubakar B.
    Grellet, Jean
    Moreau, Stephane
    Caignard, Daniel-Henri
    Jarry, Christian
    Quentin, Claudine
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (03) : 831 - 838
  • [42] FUNCTIONAL-ANALYSIS OF THE OUTB GENE OF BACILLUS-SUBTILIS
    CARAMORI, T
    CALOGERO, S
    ALBERTINI, AM
    GALIZZI, A
    JOURNAL OF GENERAL MICROBIOLOGY, 1993, 139 : 31 - 37
  • [43] IDENTIFICATION OF STRUCTURAL GENE OF LEVANSUCRASE IN BACILLUS-SUBTILIS MARBURG
    LEPESANT, JA
    LEPESANT, J
    PASCAL, M
    KUNST, F
    BILLAULT, A
    DEDONDER, R
    MOLECULAR AND GENERAL GENETICS, 1974, 128 (03): : 213 - 221
  • [44] Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus
    Brawley, Douglas N.
    Sauer, David B.
    Li, Jianping
    Zheng, Xuhui
    Koide, Akiko
    Jedhe, Ganesh S.
    Suwatthee, Tiffany
    Song, Jinmei
    Liu, Zheng
    Arora, Paramjit S.
    Koide, Shohei
    Torres, Victor J.
    Wang, Da-Neng
    Traaseth, Nathaniel J.
    NATURE CHEMICAL BIOLOGY, 2022, 18 (07) : 706 - +
  • [45] Thymoquinone' potent impairment of multidrug-resistant Staphylococcus aureus NorA efflux pump activity
    Ahmad, Adel Attia M.
    Abdelgalil, Sara Y.
    Khamis, Tarek
    Abdelwahab, Ashraf M. O.
    Atwa, Dina Nader
    Elmowalid, Gamal A.
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [46] PURIFICATION IN A FUNCTIONAL FORM OF THE TERMINAL PROTEIN OF BACILLUS-SUBTILIS PHAGE-PHI-29
    PRIETO, I
    LAZARO, JM
    GARCIA, JA
    HERMOSO, JM
    SALAS, M
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (06): : 1639 - 1643
  • [47] Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus
    Kumar, Ashwani
    Khan, Inshad Ali
    Koul, Surrinder
    Koul, Jawahir Lal
    Taneja, Subhash Chandra
    Ali, Intzar
    Ali, Furqan
    Sharma, Sandeep
    Mirza, Zahid Mehmood
    Kumar, Manoj
    Sangwan, Pyare Lal
    Gupta, Pankaj
    Thota, Niranjan
    Qazi, Ghulam Nabi
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (06) : 1270 - 1276
  • [48] STRUCTURAL AND GERMINATION DEFECTS OF BACILLUS-SUBTILIS SPORES WITH ALTERED CONTENTS OF A SPORE COAT PROTEIN
    BOURNE, N
    FITZJAMES, PC
    ARONSON, AI
    JOURNAL OF BACTERIOLOGY, 1991, 173 (20) : 6618 - 6625
  • [49] Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus
    Douglas N. Brawley
    David B. Sauer
    Jianping Li
    Xuhui Zheng
    Akiko Koide
    Ganesh S. Jedhe
    Tiffany Suwatthee
    Jinmei Song
    Zheng Liu
    Paramjit S. Arora
    Shohei Koide
    Victor J. Torres
    Da-Neng Wang
    Nathaniel J. Traaseth
    Nature Chemical Biology, 2022, 18 : 706 - 712
  • [50] The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump
    Sanchez, L
    Pan, W
    Vinas, M
    Nikaido, H
    JOURNAL OF BACTERIOLOGY, 1997, 179 (21) : 6855 - 6857
12345