THE FATE OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE AMINOPEPTIDASES UPON CELL STIMULATION WITH PHAGOCYTIC AND CHEMICAL STIMULI

被引：1

作者：

GRDISA, M ^{[1
]}

VITALE, L ^{[1
]}

机构：

[1] RUDJER BOSKOVIC INST, DEPT ORGAN CHEM & BIOCHEM, YU-41001 ZAGREB, CROATIA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1991年 / 23卷 / 09期

关键词：

D O I：

10.1016/0020-711X(91)90072-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. After being treated with nonopsonized zymosan A or phorbol-12-myristate-13-acetate, human polymorphonuclear leukocytes release aminopeptidases together with granules marker-enzymes and vitamin B-12-binding protein. 2. Chemotactic peptide, fMet-Leu-Phe and its analogs, fMet-Phe, fMet-Ala and fMet-Leu-Phe-Lys have a similar effect. 3. By their isoelectric point determinations the released aminopeptidases correspond to the enzymes from granules. Among aminopeptidases released the highest activities were those toward methionine- and alanine-2-naphthylamide and the lowest one toward arginine-2-naphthylamide.

引用

页码：863 / 866

页数：4

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