IMPROVEMENTS OF DISSOLUTION CHARACTERISTICS AND CHEMICAL-STABILITY OF 16,16-DIMETHYL-TRANS-DELTA-2-PROSTAGLANDIN-E1 METHYL-ESTER BY CYCLODEXTRIN COMPLEXATION

被引：28

作者：

UEKAMA, K

HIRAYAMA, F

YAMADA, Y

INABA, K

IKEDA, K

机构：

[1] Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto

[2] One pharmaceutical Co, Ltd., Osaka

[3] Nagoya City University, Nagoya

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 08期

关键词：

Complexation— prostaglandin E[!sub]1[!/sub] with cyclodextrin; dissolution; stability; Cyclodextrin—complexation with prostaglandin E[!sup]1[!/sup; Prostaglandin E[!sub]1[!/sub] derivatives ‐ cyclodextrin complexation;

D O I：

10.1002/jps.2600680838

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inclusion complexation of 16,16‐dimethyul‐trans‐Δ2‐prostaglandin E1 methyl ester (I), which is effective in early pregnancy termination, with cyclodextrins in water was ascertained by a solubility study. A solid complex of I‐ β‐cyclodextrin in a 1:2 molar ratio was obtained, and its dissolution behavior and chemical stability were examined. The results indicated that the complex may have great utility as a rapidly dissolving form of I with prolonged storage time. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1059 / 1060

页数：2

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