OPIATE ANTAGONISTS - ROLE IN THE TREATMENT OF HYPOVOLEMIC SHOCK

被引：427
作者：
FADEN, AI
HOLADAY, JW
机构：
[1] Department of Medical Neurosciences, Division of Neuropsychiatry, Walter Reed Army Institute of Research, Washington
来源：
SCIENCE | 1979年 / 205卷 / 4403期
关键词：
D O I：
10.1126/science.451606
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The opiate antagonist naloxone has been used to treat shock following acute blood loss in conscious rats. Naloxone treatment rapidly increased mean arterial pressure and pulse pressure in this new shock model. More importantly, these blood pressure changes were sustained and survival was significantly increased with naloxone as compared with placebo treatment. From these findings, it may be inferred that endorphins may play a role in the pathophysiology of hypovolemic shock. It is suggested that narcotic antagonists may prove to be of therapeutic value in the treatment of shock.
引用
收藏
页码：317 / 318
页数：2
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