The emerging role of oncolytic virus therapy against cancer

被引：101
作者：
Russell, Luke [1 ]
Peng, Kah-Whye [2 ]
机构：
[1] Vyriad, Rochester, MN USA
[2] Mayo Clin, 200 First St SW, Rochester, MN 55905 USA
来源：
CHINESE CLINICAL ONCOLOGY | 2018年 / 7卷 / 02期
关键词：
Cancer; oncolytic; virus; antitumor immunity;
D O I：
10.21037/cco.2018.04.04
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This review discusses current clinical advancements in oncolytic viral therapy, with a focus on the viral platforms approved for clinical use and highlights the benefits each platform provides. Three oncolytic viruses (OVs), an echovirus, an adenovirus, and a herpes simplex-1 virus, have passed governmental regulatory approval in Latvia, China, and the USA and EU. Numerous other recombinant viruses from diverse families are in clinical testing in cancer patients and we highlight the design features of selected examples, including adenovirus, herpes simplex virus, measles virus, retrovirus, reovirus, vaccinia virus, vesicular stomatitis virus. Lastly, we provide thoughts on the path forward for this rapidly expanding field especially in combination with immune modulating drugs.
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页数：13
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