INVASIVE HAEMOPHILUS-INFLUENZAE DISEASE - EPIDEMIOLOGY AND CLINICAL SPECTRUM BEFORE LARGE-SCALE HAEMOPHILUS-INFLUENZAE TYPE-B VACCINATION

被引：32
作者：
HUGOSSON, S
SILFVERDAL, SA
GARPENHOLT, O
ESBJORNER, E
LINDQUIST, B
VIKERFORS, T
WERNER, B
OLCEN, P
机构：
[1] OREBRO MED CTR HOSP,DEPT PAEDIAT,S-70185 OREBRO,SWEDEN
[2] OREBRO MED CTR HOSP,DEPT CLIN MICROBIOL & IMMUNOL,S-70185 OREBRO,SWEDEN
[3] OREBRO MED CTR HOSP,DEPT INFECT DIS,S-70185 OREBRO,SWEDEN
[4] OREBRO MED CTR HOSP,DEPT COMMUNITY MED & PUBL HLTH,S-70185 OREBRO,SWEDEN
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 1995年 / 27卷 / 01期
关键词：
D O I：
10.3109/00365549509018974
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In a prospective study between January 1987 and December 1992, 103 patients with invasive Haemophilus influenzae (Hi) infection were identified in a well-defined population before large-scale Haemophilus influenzae type b (Hib) vaccination was introduced. The incidence (cases/100,000/year) of invasive Hi infection was 5.9 for the whole population, 55 for children 0-4 years old and as high as 2.8 for adults. Hib was the predominant cause of the infection (83 cases) in children but, in adults, 13/39 (30%) cases were caused by non-typable Hi and 6/39 (19%) by Hi serotype f. Three patients (3%) died and 6 (5.8%) suffered a permanent sequel from the infection. All patients with such a sequel had invasive Hib infection. No significant difference between patients 0-6 years old and matched controls regarding the frequency of subnormal serum levels of immunoglobulins was found.
引用
收藏
页码：63 / 67
页数：5
相关论文
共 25 条
[1]   DECLINE OF CHILDHOOD HAEMOPHILUS-INFLUENZAE TYPE-B (HIB) DISEASE IN THE HIB VACCINE ERA [J].
ADAMS, WG ;
DEAVER, KA ;
COCHI, SL ;
PLIKAYTIS, BD ;
ZELL, ER ;
BROOME, CV ;
WENGER, JD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (02) :221-226
[2]   BACTERICIDAL AND OPSONIC ACTIVITY OF IGG1 AND IGG2 ANTICAPSULAR ANTIBODIES TO HAEMOPHILUS-INFLUENZAE TYPE-B [J].
AMIR, J ;
SCOTT, MG ;
NAHM, MH ;
GRANOFF, DM .
JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (01) :163-171
[3]   ENZYME-LINKED IMMUNOSORBENT-ASSAY FOR TITRATION OF HEMOPHILUS-INFLUENZAE CAPSULAR AND O ANTIGEN ANTIBODIES [J].
DAHLBERG, T ;
BRANEFORS, P .
JOURNAL OF CLINICAL MICROBIOLOGY, 1980, 12 (02) :185-192
[4]   POPULATION-BASED STUDY OF NONTYPABLE HAEMOPHILUS-INFLUENZAE INVASIVE DISEASE IN CHILDREN AND NEONATES [J].
FALLA, TJ ;
DOBSON, SRM ;
CROOK, DWM ;
KRAAK, WAG ;
NICHOLS, WW ;
ANDERSON, EC ;
JORDENS, JZ ;
SLACK, MPF ;
MAYONWHITE, D ;
MOXON, ER .
LANCET, 1993, 341 (8849) :851-854
[5]   INVASIVE HAEMOPHILUS-INFLUENZAE DISEASE IN ADULTS - A PROSPECTIVE, POPULATION-BASED SURVEILLANCE [J].
FARLEY, MM ;
STEPHENS, DS ;
BRACHMAN, PS ;
HARVEY, RC ;
SMITH, JD ;
WENGER, JD .
ANNALS OF INTERNAL MEDICINE, 1992, 116 (10) :806-812
[6]   EPIDEMIOLOGY OF INVASIVE HAEMOPHILUS-INFLUENZAE TYPE-B INFECTIONS IN GENEVA, SWITZERLAND, 1976 TO 1989 [J].
GERVAIX, A ;
SUTER, S .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1991, 10 (05) :370-374
[7]   COMPLICATION OF ACUTE EPIGLOTTITIS [J].
GONZALEZ, C ;
GARTNER, JC ;
CASSELBRANT, ML ;
KENNA, MA .
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 1986, 11 (01) :67-71
[8]   IMMUNOGLOBULIN DEFICIENCY AND IDIOTYPE EXPRESSION IN CHILDREN DEVELOPING HAEMOPHILUS-INFLUENZAE TYPE-B DISEASE AFTER VACCINATION WITH CONJUGATE VACCINE [J].
HOLMES, SJ ;
LUCAS, AH ;
OSTERHOLM, MT ;
FROESCHLE, JE ;
GRANOFF, DM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (14) :1960-1965
[9]   CHILDHOOD EPIGLOTTITIS IN RECENT YEARS [J].
KESSLER, A ;
WETMORE, RF ;
MARSH, RR .
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 1993, 25 (1-3) :155-162
[10]  
MAYOSMITH MF, 1986, NEW ENGL J MED, V324, P1133
123