A CELL-SPECIFIC NUCLEAR RECEPTOR IS ESSENTIAL FOR ADRENAL AND GONADAL DEVELOPMENT AND SEXUAL-DIFFERENTIATION

被引:1306
作者
LUO, XR
IKEDA, YY
PARKER, KL
机构
[1] DUKE UNIV,MED CTR,DEPT PHARMACOL,DURHAM,NC 27710
[2] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DURHAM,NC 27710
关键词
D O I
10.1016/0092-8674(94)90211-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene, which encodes SF-1, to examine its role in intact mice. Despite normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of death. Male and female Ftz-F1 null mice had female internal genitalia, despite complete gonadal agenesis. These studies establish that the Ftz-F1 gene is essential for sexual differentiation and formation of the primary steroidogenic tissues.
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收藏
页码:481 / 490
页数:10
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