Genome wide binding (ChIP-Seq) of murine Bapx1 and Sox9 proteins in vivo and in vitro

被引：2

作者：

Chatterjee, Sumantra ^{[1
]}

Kraus, Petra ^{[2
]}

Sivakamasundari, V. ^{[3
]}

Yap, Sook Peng ^{[4
]}

Kumar, Vibhor ^{[5
]}

Prabhakar, Shyam ^{[5
]}

Lufkin, Thomas ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, 733 N Broadway, Baltimore, MD 21205 USA

[2] Clarkson Univ, Dept Biol, 8 Clarkson Ave, Potsdam, NY 13699 USA

[3] Jackson Lab Genom Med, 10 Discovery Dr, Farmington, CT 06030 USA

[4] Apta Biosci, 31 Biopolis Way, Singapore 138669, Singapore

[5] Genome Inst Singapore, 60 Biopolis St, Singapore 138672, Singapore

来源：

GENOMICS DATA | 2016年 / 10卷

关键词：

Genome binding; Bapx1; Mouse; ChIP-Seq; Occupancy profiling by NGS;

D O I：

10.1016/j.gdata.2016.09.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This work pertains to GEO submission GSE36672, in vivo and in vitro genomewide binding (ChIP-Seq) of Bapx1/Nkx3.2 and Sox9 proteins. We have previously shown that data from a genome wide binding assay combined with transcriptional profiling is an insightful means to divulge the mechanisms directing cell type specification and the generation of tissues and subsequent organs [1]. Our earlier work identified the role of the DNA-binding homeodomain containing protein Bapx1/Nkx3.2 in midgestation murine embryos. Microarray analysis of EGFP-tagged cells (both wildtype and null) was integrated using ChIP-Seq analysis of Bapx1/Nkx3.2 and Sox9 DNA-binding proteins in living tissue. (C) 2016 The Authors. Published by Elsevier Inc.

引用

页码：51 / 53

页数：3

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