EFFICACY OF VARIOUS OXIMES AGAINST GF (CYCLOHEXYL METHYLPHOSPHONOFLUORIDATE) POISONING IN MICE

被引：31

作者：

CLEMENT, JG

机构：

[1] Biomedical Defence Section, Defence Research Establishment Suffield, Ralston, Alta.

来源：

ARCHIVES OF TOXICOLOGY | 1992年 / 66卷 / 02期

关键词：

HI-6 [CAS REG NO 34433-31-3; 1-(((4-(AMINOCARBONYL)PYRIDINIO)METHOXY)METHYL)-2-((HYDROXY-IMINO)METHYL)-PYRIDINIUM DICHLORIDE; OXIME; GF (CYCLOHEXYL METHYLPHOSPHONOFLUORIDATE); SARIN; ORGANOPHOSPHATE; POISONING; ACETYLCHOLINESTERASE; INHIBITOR; REACTIVATION; TOXICITY; TOXOGONIN; PAM (PYRIDINE 2-ALDOXIME);

D O I：

10.1007/BF02342509

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime which reactivated GF inhibited acetylcholinesterase. This might explain the reason why the HI-6 treated mice appeared to recover more quickly from the incapacitating effects following GF poisoning.

引用

页码：143 / 144

页数：2

共 5 条

[1] EFFICACY OF MONO-PYRIDINIUM AND BIS-PYRIDINIUM OXIMES VERSUS SOMAN, SARIN AND TABUN POISONING IN MICE [J].