NUCLEOSIDES .156. 5'-HYDROGENPHOSPHONATES AND 5'-METHYLPHOSPHONATES OF SUGAR MODIFIED PYRIMIDINE NUCLEOSIDES AS POTENTIAL ANTI-HIV-1 AGENTS

被引：34

作者：

KRAYEVSKY, AA

TARUSSOVA, NB

ZHU, QY

VIDAL, P

CHOU, TC

BARON, P

POLSKY, B

JIANG, XJ

MATULICADAMIC, J

ROSENBERG, I

WATANABE, KA

机构：

[1] MEM SLOAN KETTERING CANC CTR, NEW YORK, NY 10021 USA

[2] ACAD SCI USSR, INST MOLEC BIOL, MOSCOW V-71, USSR

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1992年 / 11卷 / 2-4期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319208021696

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of nucleoside 5'-hydrogenphosphonates and nucleoside 5'-methylphosphonates were prepared, to study their ability to inhibit replication of HIV-1. Two compounds, the 5'-hydrogenphosphonate of 3'-azido-3'-deoxythymidine (AZT-HP, IVc) and of 3'-deoxy-3'-fluorothymidine (FLT-HP, IVa), exhibit potent anti-HIV-1 activity with selectivity indices similar to or better than those of their parent nucleosides.

引用

页码：177 / 196

页数：20

共 34 条

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[2]

BEABEALASHVILLI RS, 1989, IN PRESS BIOESSAYS

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