MERSACIDIN, A NEW ANTIBIOTIC FROM BACILLUS INVITRO AND INVIVO ANTIBACTERIAL ACTIVITY

被引：88

作者：

CHATTERJEE, S ^{[1
]}

CHATTERJEE, DK ^{[1
]}

JANI, RH ^{[1
]}

BLUMBACH, J ^{[1
]}

GANGULI, BN ^{[1
]}

KLESEL, N ^{[1
]}

LIMBERT, M ^{[1
]}

SEIBERT, G ^{[1
]}

机构：

[1] HOECHST AG,PHARMA RES,W-6230 FRANKFURT 80,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 06期

关键词：

D O I：

10.7164/antibiotics.45.839

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mersacidin is a new peptide antibiotic of the proposed lantibiotic family. It is active in vitro and in vivo against Gram-positive bacteria including the methicillin-resistant Staphylococci. Its in vitro activity is less than those of vancomycin and erythromycin but it shows much higher activity in the in vivo system than can be expected from the in vitro testing results. A water soluble potassium salt has been prepared which has an activity profile similar to that of mersacidin, but has better in vivo activity against Streptococcus pyogenes than the parent compound.

引用

页码：839 / 845

页数：7

共 7 条

[1] MERSACIDIN, A NEW ANTIBIOTIC FROM BACILLUS FERMENTATION, ISOLATION, PURIFICATION AND CHEMICAL CHARACTERIZATION [J].