ASSIGNMENT OF THE HUMAN INTERFERON REGULATORY FACTOR-I (IRF1) GENE TO CHROMOSOME 5Q23-Q31

被引：51

作者：

ITOH, S

HARADA, H

NAKAMURA, Y

WHITE, R

TANIGUCHI, T

机构：

[1] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,SUITA,OSAKA 565,JAPAN

[2] UNIV UTAH,MED CTR,DEPT HUMAN GENET,SALT LAKE CITY,UT 84132

[3] UNIV UTAH,MED CTR,HOWARD HUGHES,SALT LAKE CITY,UT 84132

来源：

GENOMICS | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90208-V

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

It has been shown that a nuclear factor, interferon regulatory factor-1 (IRF1), plays a key role in the regulation of the type I interferon (IFN) system by affecting the transcription of type I IFN and some IFN-inducible genes. In this study, the human IRF1 gene was mapped to chromosome 5 by analysis of mouse-human somatic cell hybrids. Furthermore, by linkage analysis based on RFLP (restriction fragment length polymorphism), the gene was localized to chromosome 5q23-q31, the region that has been termed "critical" for some myeloid disorders. © 1991.

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页码：1097 / 1099

页数：3

相关论文

共 13 条

[1] INDUCTION OF THE TRANSCRIPTION FACTOR IRF-1 AND INTERFERON-BETA MESSENGER-RNAS BY CYTOKINES AND ACTIVATORS OF 2ND-MESSENGER PATHWAYS [J].

FUJITA, T ;

REIS, LFL ;

WATANABE, N ;

KIMURA, Y ;

TANIGUCHI, T ;

VILCEK, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9936-9940

[2] INDUCTION OF ENDOGENOUS IFN-ALPHA AND IFN-BETA GENES BY A REGULATORY TRANSCRIPTION FACTOR, IRF-1 [J].

FUJITA, T ;

KIMURA, Y ;

MIYAMOTO, M ;

BARSOUMIAN, EL ;

TANIGUCHI, T .

NATURE, 1989, 337 (6204) :270-272

[3] ABSENCE OF THE TYPE-I IFN SYSTEM IN EC CELLS - TRANSCRIPTIONAL ACTIVATOR (IRF-1) AND REPRESSOR (IRF-2) GENES ARE DEVELOPMENTALLY REGULATED [J].

HARADA, H ;

WILLISON, K ;

SAKAKIBARA, J ;

MIYAMOTO, M ;

FUJITA, T ;

TANIGUCHI, T .

CELL, 1990, 63 (02) :303-312

[4] PRIMARY STRUCTURE OF HUMAN PANCREATIC SECRETORY TRYPSIN-INHIBITOR (PSTI) GENE [J].

HORII, A ;

KOBAYASHI, T ;

TOMITA, N ;

YAMAMOTO, T ;

FUKUSHIGE, S ;

MUROTSU, T ;

OGAWA, M ;

MORI, T ;

MATSUBARA, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 149 (02) :635-641

[5]

LATHROP GM, 1985, AM J HUM GENET, V37, P482

[6]

LATHROP GM, 1988, GENOMICS, V2, P157

[7] CLINICAL AND CYTOGENETIC CORRELATIONS IN 63 PATIENTS WITH THERAPY-RELATED MYELODYSPLASTIC SYNDROMES AND ACUTE NONLYMPHOCYTIC LEUKEMIA - FURTHER EVIDENCE FOR CHARACTERISTIC ABNORMALITIES OF CHROMOSOME-5 AND CHROMOSOME-7 [J].

LEBEAU, MM ;

ALBAIN, KS ;

LARSON, RA ;

VARDIMAN, JW ;

DAVIS, EM ;

BLOUGH, RR ;

GOLOMB, HM ;

ROWLEY, JD .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (03) :325-345

[8] SEQUENCE OF A CDNA CODING FOR HUMAN IRF-1 [J].

MARUYAMA, M ;

FUJITA, T ;

TANIGUCHI, T .

NUCLEIC ACIDS RESEARCH, 1989, 17 (08) :3292-3292

[9] REGULATED EXPRESSION OF A GENE ENCODING A NUCLEAR FACTOR, IRF-1, THAT SPECIFICALLY BINDS TO IFN-BETA-GENE REGULATORY ELEMENTS [J].

MIYAMOTO, M ;

FUJITA, T ;

KIMURA, Y ;

MARUYAMA, M ;

HARADA, H ;

SUDO, Y ;

MIYATA, T ;

TANIGUCHI, T .

CELL, 1988, 54 (06) :903-913

[10]

NAKAMURA Y, 1988, AM J HUM GENET, V43, P638