GENE STRUCTURE OF MOUSE CATHEPSIN-B

被引：27

作者：

FERRARA, M

WOJCIK, F

RHAISSI, H

MORDIER, S

ROUX, MP

BECHET, D

机构：

[1] Unité de Recherches sur l'expression desprotćases, SRV Theix, Institut Natlonal de la Recherche Agronomique

来源：

FEBS LETTERS | 1990年 / 273卷 / 1-2期

关键词：

Cathepsin B; Cysteine proteinase; Gene structure;

D O I：

10.1016/0014-5793(90)81083-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of a genomic DNA fragment encoding mouse cathepsin B was characterized. The genomic insert spans 15 kbp and contains 9 exons encoding the 339 amino acid residues of mouse preprocathepsin B. Intron break-points are not found at the junctions of the pre-peptide, pro-peptide and mature enzyme. Like other cysteine proteinase genes, the region around the cysteinyl active site is split by an intron, but in contrast with cathepsins L and H the intron break-point is located immediately after the active site. © 1990.

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页码：195 / 199

页数：5

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