SEROTONERGIC ANTAGONISTS AND VASCULAR-DISEASE

被引：20

作者：

VANHOUTTE, PM

机构：

[1] Baylor College of Medicine, Houston, TX

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1990年 / 4卷

关键词：

adrenergic nerves; atherosclerosis; endothelium; endothelium-derived contracting factor; endothelium-derived relaxing factor; hypertension; regenerated endothelium; serotonin;

D O I：

10.1007/BF00053420

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

5-Hydroxytryptamine (serotonin) can evoke both contraction and relaxation of vascular smooth muscle. In disease, the constrictor component of the response to the monoamine appears to dominate. 5HT2-serotonergicantagonists favor dilatation, not only because they block the activating effect of serotonin on vascular smooth muscle, but also because they unmask the (endothelium-dependent) relaxation to the monoamine and brake the amplifying effect that it exerts on platelet aggregation. These properties of serotonergic antagonists help to explain their protective effects in vascular disease. © 1990 Kluwer Academic Publishers.

引用

页码：7 / 12

页数：6

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